Electrophysiological characteristics and pharmacological sensitivity of two lines of human induced pluripotent stem cell derived cardiomyocytes coming from two different suppliers.

Tenascin-C promotes tumor cell migration and metastasis through integrin α9β1-mediated YAP inhibition.

Parkinson’s disease (PD) affects 1-2 per 1000 of the general population. PD prevalence is increasing with age and PD affects 1% of …

Proarrhythmic risk assessment using conventional and new in vitro assays.

Stimulant drugs produce reward but also activate stress-responsive systems. The corticotropin-releasing factor (CRF) and the related hypothalamus-pituitary-adrenal (HPA) axis stress-responsive systems are …

Gastric mucosa is frequently exposed to various gastric irritants, and there is a continuing requirement to develop new gastro-protective agents. This study …

Efficacy of anticonvulsant substances in the 6Hz seizure test: Comparison of two rodent species

At present there is no satisfactory treatment against relapse of drug-seeking behavior. Relapse can be modeled in laboratory animals using reinstatement procedures, …

The guidelines from different agencies do not include studies on cognitive functions as part of safety pharmacology. This is unfortunate as it …

Comparison of three preclinical models for nausea and vomiting assessment