RESPIRATORY SYSTEM
The effects of compounds and therapies on the respiratory system can be assessed using a variety of models, and species, with which Porsolt has extensive experience. These models can be used for assessing the efficacy and/or safety of compounds, and include models for airway function, asthma, cough, fibrosis, bronchospasm, etc.
SCROLL
RESPIRATORY SYSTEM
EX-VIVO MODELS
IN VIVO MODELS
| Isolated pulmonary artery | Rat |
| Isolated trachea | Rat – Guinea-pig |
| Airway function (whole body plethysmography) | Mouse – Rat - Guinea-pig |
| Airway function in large animals | Dogs |
| Airway function under hypercapnia (whole body plethysmography) | Rat |
| Bleomycin-induced pulmonary fibrosis | Mouse |
| Citric acid-induced cough | Guinea-pig |
| Histamine bronchospasm | Guinea-pig |
| LPS-induced pulmonary injury | Mouse |
| Ovalbumin-induced asthma | Guinea-pig |
BIOMARKER ASSAYS
| PLATFORM | BIOMARKER | SPECIES (SAMPLE) |
|---|---|---|
| Staining (paraffin slices) | Hepatic transporters (MRP-2, ZO-1,…) | Multiple species & tissues |
| CBA | TNF, IL-6, IL-1β , IL-10 and MCP-1 | Mouse (BAL) |
| Biochemical | MPO activity | Mouse (whole lung) |
| Hematology | WBC (White Blood Cell count): Neutrophils, Macrophages, Lymphocytes, Eosinophils,Basophils | Mouse (BAL) |
| ELISA | TNF, IL-6, IL-1β | Mouse (BAL) |
| CBA–ELISA–WB–IHC-PIHC-Fr–ICC–HTRF | Other targets upon request | Multiple species & biological specimens |
