RESPIRATORY SYSTEM
The effects of compounds and therapies on the respiratory system can be assessed using a variety of models, and species, with which Porsolt has extensive experience. These models can be used for assessing the efficacy and/or safety of compounds, and include models for airway function, asthma, cough, fibrosis, bronchospasm, etc.
SCROLL

RESPIRATORY SYSTEM
EX-VIVO MODELS
IN VIVO MODELS
Isolated pulmonary artery | Rat |
Isolated trachea | Rat – Guinea-pig |
Airway function (whole body plethysmography) | Mouse – Rat - Guinea-pig |
Airway function in large animals | Dogs |
Airway function under hypercapnia (whole body plethysmography) | Rat |
Bleomycin-induced pulmonary fibrosis | Mouse |
Citric acid-induced cough | Guinea-pig |
Histamine bronchospasm | Guinea-pig |
LPS-induced pulmonary injury | Mouse |
Ovalbumin-induced asthma | Guinea-pig |
BIOMARKER ASSAYS
PLATFORM | BIOMARKER | SPECIES (SAMPLE) |
---|---|---|
Staining (paraffin slices) | Hepatic transporters (MRP-2, ZO-1,…) | Multiple species & tissues |
CBA | TNF, IL-6, IL-1β , IL-10 and MCP-1 | Mouse (BAL) |
Biochemical | MPO activity | Mouse (whole lung) |
Hematology | WBC (White Blood Cell count): Neutrophils, Macrophages, Lymphocytes, Eosinophils,Basophils | Mouse (BAL) |
ELISA | TNF, IL-6, IL-1β | Mouse (BAL) |
CBA–ELISA–WB–IHC-PIHC-Fr–ICC–HTRF | Other targets upon request | Multiple species & biological specimens |
Porsolt
Z.A. de Glatigné
53940 Le Genest-Saint-Isle, France
Telephone +33 2 43 69 36 07
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