RESPIRATORY SYSTEM

The effects of compounds and therapies on the respiratory system can be assessed using a variety of models, and species, with which Porsolt has extensive experience. These models can be used for assessing the efficacy and/or safety of compounds, and include models for airway function, asthma, cough, fibrosis, bronchospasm, etc.

SCROLL

lungs

RESPIRATORY SYSTEM

EX-VIVO MODELS
Isolated pulmonary artery Rat
Isolated trachea Rat – Guinea-pig
IN VIVO MODELS
Airway function (whole body plethysmography) Mouse – Rat - Guinea-pig
Airway function in large animals Dogs
Airway function under hypercapnia (whole body plethysmography) Rat
Bleomycin-induced pulmonary fibrosis Mouse
Citric acid-induced cough Guinea-pig
Histamine bronchospasm Guinea-pig
LPS-induced pulmonary injury Mouse
Ovalbumin-induced asthma Guinea-pig
BIOMARKER ASSAYS
PLATFORM BIOMARKER SPECIES (SAMPLE)
Staining (paraffin slices) Hepatic transporters (MRP-2, ZO-1,…) Multiple species & tissues
CBA TNF, IL-6, IL-1β , IL-10 and MCP-1 Mouse (BAL)
Biochemical MPO activity Mouse (whole lung)
Hematology WBC (White Blood Cell count): Neutrophils, Macrophages, Lymphocytes, Eosinophils,Basophils Mouse (BAL)
ELISA TNF, IL-6, IL-1β Mouse (BAL)
CBA–ELISA–WB–IHC-PIHC-Fr–ICC–HTRF Other targets upon request Multiple species & biological specimens

Porsolt

Z.A. de Glatigné
53940 Le Genest-Saint-Isle, France
Telephone +33 2 43 69 36 07

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