The aim of the present study was to evaluate the utility of different tests performed in the absence or presence of factors …

Several methods are used to evaluate gastric emptying (GE) in rats, which is an important endpoint in preclinical drug development. Although phenol …

Nausea and vomiting are common side effects of cancer chemotherapy. We have previously described a model in the ferret where delayed emesis …

We compared the preclinical analgesic activity of three marketed drugs with different pharmacological properties, pregabalin, tramadol and duloxetine, described as effective against …

Collection of formulation samples is required for GLP in vitro studies to check the exposure of the test system and allow reliable …

Nausea and vomiting are common side effects of cancer chemotherapy. The ferret is a highly appropriate animal species to evaluate both early …

The present paper will suggest, on the basis of experimental evidence, that several non-human primate (NHP) procedures can be uniquely useful and …

Repeated haloperidol treatment administered to nonhuman primates (NHPs) over several months or even years leads to the gradual appearance of drug-induced dystonic …

Safety pharmacology entails the assessment of the potential risks of novel pharmaceuticals for human use. As detailed in the ICH S7A guidelines, …

Hydroxypropyl-β-cyclodextrin (HPβCD) is a complexation agent used to enhance drug solubilization and formulation stability. Although its toxicity is well characterized, its cardiovascular …