News & Publications

On this page, you can find our publications in different disease areas and all the latest news and updates related to Porsolt.

Central Nervous System

The aim of the present study was to evaluate the utility of different tests performed in the absence or presence of factors …

gastro-intestinal system

Several methods are used to evaluate gastric emptying (GE) in rats, which is an important endpoint in preclinical drug development. Although phenol …

gastro-intestinal system

Nausea and vomiting are common side effects of cancer chemotherapy. We have previously described a model in the ferret where delayed emesis …

Inflammation

We compared the preclinical analgesic activity of three marketed drugs with different pharmacological properties, pregabalin, tramadol and duloxetine, described as effective against …

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Collection of formulation samples is required for GLP in vitro studies to check the exposure of the test system and allow reliable …

gastro-intestinal system

Nausea and vomiting are common side effects of cancer chemotherapy. The ferret is a highly appropriate animal species to evaluate both early …

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The present paper will suggest, on the basis of experimental evidence, that several non-human primate (NHP) procedures can be uniquely useful and …

Central Nervous System

Repeated haloperidol treatment administered to nonhuman primates (NHPs) over several months or even years leads to the gradual appearance of drug-induced dystonic …

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Safety pharmacology entails the assessment of the potential risks of novel pharmaceuticals for human use. As detailed in the ICH S7A guidelines, …

urogenital system

Hydroxypropyl-β-cyclodextrin (HPβCD) is a complexation agent used to enhance drug solubilization and formulation stability. Although its toxicity is well characterized, its cardiovascular …

Porsolt

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