GASTRO-INTESTINAL SYSTEM : Advancing the Understanding of Gastrointestinal Health
Porsolt, as a GI CRO (Gastrointestinal Contract Research Organization), brings a depth of experience in gastrointestinal efficacy pharmacology and safety assessment. Our focus is on providing a variety of models that cater to different aspects of gastrointestinal research. In our ongoing effort to contribute to the field, we are dedicated to the continual development and validation of new, pertinent models for GI research.
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gastro-intestinal DISEASE
Colonic Motility
Colonic motility is the movement of food through the colon. GI CROs like Porsolt study colonic motility by using GI in vivo models, GI histology, GI lab tests, and preclinical medical devices. This helps improve understanding of colonic motility and develop treatments for colon disorders.
| Anti-diarrhea (castor oil) | Mouse - Rat |
| Colonic transit (bead model) | Mouse - Rat |
| Fecal consistency | Mouse - Rat |
Emesis - Nausea
Emesis, or vomiting, is the forceful expulsion of stomach contents through the mouth. It is often accompanied by nausea, a feeling of uneasiness or discomfort in the stomach. Our GI CRO capabilities include a variety of techniques to study emesis and develop solutions for patients.
| Early and delayed emesis (telemetry) | Ferret |
| Early anti-emetic activity (morphine, cisplatin, emetine,…) | Ferret |
| Emesis induction | Ferret |
| Pica behavior | Rat |
Food Allergy
Food allergy is an abnormal immune response to food that can cause a range of symptoms, from mild to severe. Our GI CRO capabilities help improve our understanding of food allergies and develop new treatments for patients under these conditions.
| Beta-lactoglobulin-induced allergy | Mouse |
| Peanut-induced allergy | Mouse |
Gastric
Emptying
Gastric emptying, facilitated by our GI CRO services, involves food transit from stomach to the intestine. Our in vivo models, GI histology, GI lab tests, and imaging aid in comprehending this process and advancing treatments.
| Gastric emptying (measurement of plasma acetaminophen levels) | Rat |
| Gastric emptying (phenol red test) | Mouse - Rat |
Gastro-intestinal
Transit
Gastrointestinal transit is the time it takes for food to travel through the digestive tract. Studied by our GI CRO's team of researchers, it is a complex process that is influenced by a variety of factors, including the type of food, the size of the meal, and the presence of disease.
| Charcoal meal test | Mouse - Rat |
| Distribution pattern of phenol red | Mouse |
Gastroparesis
Gastroparesis is a disorder of the stomach that affects its ability to empty food. Our GI CRO scientists study it using in vivo model, gastrointestinal histology, GI lab tests, and imaging. This helps improve understanding of gastroparesis and develop treatments.
| Clonidine-induced delayed gastric emptying (liquid meal) | Rat |
| Clonidine-induced delayed gastricemptying (solid meal) | Rat |
| Post operative ileus | Mouse |
Intestinal
Mucositis
Our GI CRO capabilities include intestinal mucositis which is inflammation and damage to the lining of the intestines. It is often caused by chemotherapy or radiation therapy, but it can also be caused by infections, autoimmune diseases, or certain medications.
| Chemotherapy-induced intestinal mucositis | Mouse - Rat |
Ulcerogenic
Activity
Ulcerogenic activity is the ability of a substance to cause ulcers in the gastrointestinal tract. It can be caused by a variety of factors, including bacteria, viruses, and chemicals. Our GI CRO scientific expertise in in vivo models, gastrointestinal histology, and bioanalysis, help study ulcerogenic activity and develop new treatments for ulcers syndrome.
| Indomethacin-induced gastric mucosal cell damage | Rat gastric mucosal cells |
| Colorectal distension (CRD model) after acetic acid sensitization | Rat |
| Colorectal distension (CRD model) after TNBS sensitization | Rat |
| Gastric acid secretion (Shay’s method) | Mouse - Rat |
| Ulcerogenic activity (acute and sub-chronic) | Rat |
| Ulcerogenic activity prevention(induced by ethanol) | Rat |
| Ulcerogenic activity prevention(induced by indomethacin) | Rat |
Visceral Smooth Muscle
Among the gastrointestinal disease services our GI CRO provides is the visceral smooth muscle. This is a type of muscle tissue that is found in the walls of internal organs, such as the stomach, intestines, and bladder. It is responsible for the involuntary movements of these organs, such as peristalsis, which is the movement of food through the digestive tract.
| Isolated colon | Guinea-pig |
| Isolated duodenum | Rat |
| Isolated ileum | Guinea-pig |
Partnering with Porsolt : Your gateway to gastrointestinal studies and advancements
As a trusted GI CRO, we take pride in our experience in collaborative partnerships with esteemed researchers, pharmaceutical companies, and biotech firms.
In summary, Porsolt’s GI CRO services offers a comprehensive suite of in vivo models, gastrointestinal histology, GI lab tests, and bioanalysis to elevate your gastroenterology research endeavors. Through collaborative partnerships, our deep expertise and a passion for continual innovation, we strive to advance the understanding of gastrointestinal health and contribute to the development of effective therapeutic solutions for better patient outcomes.
| PLATFORM | BIOMARKER | SPECIES (SAMPLE) |
|---|---|---|
| Staining (paraffin slices) | Hematoxylin & Eosin, Sirius red, Masson’s trichrome… | Multiple species & tissues |
| CBA | Inflammatory cytokines: IL-1α , IL-1β , IL-6, IL-10, MCP-1 and TNF | Mouse (ileum, plasma) In development |
| Biochemical | MPO activity | Mouse, Rat (serum, plasma) |
| Ammonia | Rat (serum, plasma) | |
| Lipid panel (HDL, LDL, GGT, FFA, TG, cholesterol …) | Mouse, Rat (serum, plasma) | |
| Liver function panel (ALAT, ASAT, ALP, bilirubin …) | Mouse, Rat (serum, plasma) | |
| ELISA | Inflammatory cytokines: TNF-α /IL-1 , IL-6 | Mouse, Rat (serum, plasma, ileum) |
| Redox potential (GSH) | Mouse, Rat (serum, plasma, ileum) | |
| Allergy (Total IgE, histamine, mMCP-1) | Mouse (plasma) | |
| CBA–ELISA–WB–IHC-PIHC-Fr–ICC–HTRF | Other targets upon request | Multiple species & biological specimens |
| Histology (IHC-P) | Neutrophils (MPO) | Mouse (intestine) |
