gastro-intestinal system
Porsolt has long-standing extensive expertise in gastrointestinal efficacy pharmacology and safety. We provide models that focus on different gastrointestinal indications and on different parts of the gastrointestinal system. Porsolt also continues to develop and validate new and relevant models.
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gastro-intestinal DISEASE
Colonic Motility
Colonic motility is defined by the movements of the digestive system, and the transit of its contents.
| Anti-diarrhea (castor oil) | Mouse - Rat |
| Colonic transit (bead model) | Mouse - Rat |
| Fecal consistency | Mouse - Rat |
Emesis - Nausea
Emesis is the act or process of vomiting caused by certain certain stimuli or agents.
| Early and delayed emesis (telemetry) | Ferret |
| Early anti-emetic activity (morphine, cisplatin, emetine,…) | Ferret |
| Emesis induction | Ferret |
| Pica behavior | Rat |
Food Allergy
Food allergy is an abnormal immune response to food with varying symptoms ranging from mild to severe.
| Beta-lactoglobulin-induced allergy | Mouse |
| Peanut-induced allergy | Mouse |
Gastric
Emptying
Gastric emptying measures the time it takes for food to empty from the stomach to the small intestine.
| Gastric emptying (measurement of plasma acetaminophen levels) | Rat |
| Gastric emptying (phenol red test) | Mouse - Rat |
Gastro-intestinal
Transit
Transit measures the time it takes for food to travel through the digestive tract.
| Charcoal meal test | Mouse - Rat |
| Distribution pattern of phenol red | Mouse |
Gastroparesis
Gastroparesis is a disease in which the stomach cannot empty itself of food in a usual fashion.
| Clonidine-induced delayed gastric emptying (liquid meal) | Rat |
| Clonidine-induced delayed gastricemptying (solid meal) | Rat |
| Post operative ileus | Mouse |
Intestinal
Mucositis
Intestinal mucositis is damage that occurs to the mucosal membrane of the gastro-intestinal tract.
| Chemotherapy-induced intestinal mucositis | Mouse - Rat |
Ulcerogenic
Activity
Ulcerogenic activity occurs as a result of different insults to the gastro-intestinal tract.
| Indomethacin-induced gastric mucosal cell damage | Rat gastric mucosal cells |
| Colorectal distension (CRD model) after acetic acid sensitization | Rat |
| Colorectal distension (CRD model) after TNBS sensitization | Rat |
| Gastric acid secretion (Shay’s method) | Mouse - Rat |
| Ulcerogenic activity (acute and sub-chronic) | Rat |
| Ulcerogenic activity prevention(induced by ethanol) | Rat |
| Ulcerogenic activity prevention(induced by indomethacin) | Rat |
Visceral Smooth Muscle
Visceral smooth muscle, is tissue associated with the internal organs of the body, especially those in the abdominal cavity.
| Isolated colon | Guinea-pig |
| Isolated duodenum | Rat |
| Isolated ileum | Guinea-pig |
| PLATFORM | BIOMARKER | SPECIES (SAMPLE) |
|---|---|---|
| Staining (paraffin slices) | Hematoxylin & Eosin, Sirius red, Masson’s trichrome… | Multiple species & tissues |
| CBA | Inflammatory cytokines: IL-1α , IL-1β , IL-6, IL-10, MCP-1 and TNF | Mouse (ileum, plasma) In development |
| Biochemical | MPO activity | Mouse, Rat (serum, plasma) |
| Ammonia | Rat (serum, plasma) | |
| Lipid panel (HDL, LDL, GGT, FFA, TG, cholesterol …) | Mouse, Rat (serum, plasma) | |
| Liver function panel (ALAT, ASAT, ALP, bilirubin …) | Mouse, Rat (serum, plasma) | |
| ELISA | Inflammatory cytokines: TNF-α /IL-1 , IL-6 | Mouse, Rat (serum, plasma, ileum) |
| Redox potential (GSH) | Mouse, Rat (serum, plasma, ileum) | |
| Allergy (Total IgE, histamine, mMCP-1) | Mouse (plasma) | |
| CBA–ELISA–WB–IHC-PIHC-Fr–ICC–HTRF | Other targets upon request | Multiple species & biological specimens |
| Histology (IHC-P) | Neutrophils (MPO) | Mouse (intestine) |
