gastro-intestinal system

Porsolt has long-standing extensive expertise in gastrointestinal efficacy pharmacology and safety. We provide models that focus on different gastrointestinal indications and on different parts of the gastrointestinal system. Porsolt also continues to develop and validate new and relevant models.

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gastro-intestinal system

gastro-intestinal DISEASE

Colonic Motility

Colonic motility is defined by the movements of the digestive system, and the transit of its contents.

IN VIVO MODELS
Anti-diarrhea (castor oil) Mouse - Rat
Colonic transit (bead model) Mouse - Rat
Fecal consistency Mouse - Rat

Emesis - Nausea

Emesis is the act or process of vomiting caused by certain certain stimuli or agents.

IN VIVO MODELS
Early and delayed emesis (telemetry) Ferret
Early anti-emetic activity (morphine, cisplatin, emetine,…) Ferret
Emesis induction Ferret
Pica behavior Rat

Food Allergy

Food allergy is an abnormal immune response to food with varying symptoms ranging from mild to severe.

IN VIVO MODELS
Beta-lactoglobulin-induced allergy Mouse
Peanut-induced allergy Mouse

Gastric
Emptying

Gastric emptying measures the time it takes for food to empty from the stomach to the small intestine.

IN VIVO MODELS
Gastric emptying (measurement of plasma acetaminophen levels) Rat
Gastric emptying (phenol red test) Mouse - Rat

Gastro-intestinal
Transit

Transit measures the time it takes for food to travel through the digestive tract.

IN VIVO MODELS
Charcoal meal test Mouse - Rat
Distribution pattern of phenol red Mouse

Gastroparesis

Gastroparesis is a disease in which the stomach cannot empty itself of food in a usual fashion.

IN VIVO MODELS
Clonidine-induced delayed gastric emptying (liquid meal) Rat
Clonidine-induced delayed gastricemptying (solid meal) Rat
Post operative ileus Mouse

Intestinal
Mucositis

Intestinal mucositis is damage that occurs to the mucosal membrane of the gastro-intestinal tract.

IN VIVO MODELS
Chemotherapy-induced intestinal mucositis Mouse - Rat

Ulcerogenic
Activity

Ulcerogenic activity occurs as a result of different insults to the gastro-intestinal tract.

IN VITRO MODELS
Indomethacin-induced gastric mucosal cell damage Rat gastric mucosal cells
IN VIVO MODELS
Colorectal distension (CRD model) after acetic acid sensitization Rat
Colorectal distension (CRD model) after TNBS sensitization Rat
Gastric acid secretion (Shay’s method) Mouse - Rat
Ulcerogenic activity (acute and sub-chronic) Rat
Ulcerogenic activity prevention(induced by ethanol) Rat
Ulcerogenic activity prevention(induced by indomethacin) Rat

Visceral Smooth Muscle

Visceral smooth muscle, is tissue associated with the internal organs of the body, especially those in the abdominal cavity.

EX VIVO MODELS
Isolated colon Guinea-pig
Isolated duodenum Rat
Isolated ileum Guinea-pig
BIOMARKER ASSAYS
PLATFORM BIOMARKER SPECIES (SAMPLE)
Staining (paraffin slices) Hematoxylin & Eosin, Sirius red, Masson’s trichrome… Multiple species & tissues
CBA Inflammatory cytokines: IL-1α , IL-1β , IL-6, IL-10, MCP-1 and TNF Mouse (ileum, plasma) In development
Biochemical MPO activity Mouse, Rat (serum, plasma)
Ammonia Rat (serum, plasma)
Lipid panel (HDL, LDL, GGT, FFA, TG, cholesterol …) Mouse, Rat (serum, plasma)
Liver function panel (ALAT, ASAT, ALP, bilirubin …) Mouse, Rat (serum, plasma)
ELISA Inflammatory cytokines: TNF-α /IL-1 , IL-6 Mouse, Rat (serum, plasma, ileum)
Redox potential (GSH) Mouse, Rat (serum, plasma, ileum)
Allergy (Total IgE, histamine, mMCP-1) Mouse (plasma)
CBA–ELISA–WB–IHC-PIHC-Fr–ICC–HTRF Other targets upon request Multiple species & biological specimens
Histology (IHC-P) Neutrophils (MPO) Mouse (intestine)

Porsolt

Z.A. de Glatigné
53940 Le Genest-Saint-Isle, France
Telephone +33 2 43 69 36 07

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