PAIN
Porsolt offers models of acute and chronic pain and inflammation matching the needs of the industry and maintaining a recognized expertise, which addresses pain therapeutic endpoints and pain associated symptoms and side effects.
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PAIN DISEASE
Acute Pain
Acute nociceptive pain develops in response to a specific situation and tends to go away as the affected area heals.
| Cold-induced hyperalgesia | Mouse - Rat |
| Hot Plate | Mouse - Rat |
| Modified Hot Plate | Mouse |
| Pain after local administration | Mouse - Rat |
| Pinchmeter | Mouse - Rat |
| Tail Flick | Mouse - Rat |
Inflammatory
Pain
Inflammatory pain can be defined as hypersensitivity in response to tissue damage and inflammation.
| Capsaicin paw | Mouse - Rat |
| Carrageenan-induced acute inflammatory pain (reversal & prevention protocol) | Rat |
| Complete Freund Adjuvant (CFA) - induced acute inflammatory pain | Mouse - Rat |
| Complete Freund Adjuvant (CFA) - induced chronic inflammatory pain: monoarthritis model | Rat |
| Formalin paw (early phase) | Mouse - Rat |
| Formalin paw (late phase) | Mouse - Rat |
| Migraine model | Mouse - Rat |
| Mono-iodoacetate (MIA) - induced chronic inflammatory pain: osteoarthritis model | Rat |
| Mono-iodoacetate (MIA) - induced lower back pain | Rat |
Neuropathic
Pain
Neuropathic pain is caused by damage or disease affecting the somatosensory nervous system and may be associated with abnormal pain from normally non-painful stimuli.
| Chemotherapy - induced periphera neuropathy (neurite outgrowth) | Peri.4U® neurons (Human) |
| Chemotherapy - induced neuropathic pain: Cisplatin | Rat |
| Chemotherapy - induced neuropathic pain: Vincristine model | Rat |
| Chronic Constrictive Injury - induced neuropathic pain: CCI/Bennett model | Mouse - Rat |
| Diabetic - induced neuropathy | Rat |
| Spinal Nerve Ligation - induced neuropathic pain: SNL/Chung model | Mouse - Rat |
Post-operative
pain
Postoperative pain is an increase in background pain that occurs following a newly created wound.
| Brennan model post-operative pain | Rat – Guinea-pig |
Visceral
pain
Visceral pain occurs in the pelvis, abdomen, chest, or intestines as a result of insult, damage, or injury to internal organs or tissues.
| Acetic acid writhing | Mouse |
| Bezold-Jarish reflex (capsaicin) (anesthetized animal) | Rat |
| Colorectal distension (CRD) after 2,4,6 -trinitrobenzenesulfonicacid (TNBS) sensitization | Rat |
| Colorectal distension (CRD) after acetic acid sensitization | Rat |
| Dextran Sodium Sulfate (DSS) - induced colitis | Mouse |
| Parabenzoquinone writhing | Mouse |
