Porsolt offers models of acute and chronic pain and inflammation matching the needs of the industry and maintaining a recognized expertise, which addresses pain therapeutic endpoints and pain associated symptoms and side effects.
Acute nociceptive pain develops in response to a specific situation and tends to go away as the affected area heals.
|Cold-induced hyperalgesia||Mouse - Rat|
|Hot Plate||Mouse - Rat|
|Modified Hot Plate||Mouse|
|Pain after local administration||Mouse - Rat|
|Pinchmeter||Mouse - Rat|
|Tail Flick||Mouse - Rat|
Inflammatory pain can be defined as hypersensitivity in response to tissue damage and inflammation.
|Capsaicin paw||Mouse - Rat|
|Carrageenan-induced acute inflammatory pain (reversal & prevention protocol)||Rat|
|Complete Freund Adjuvant (CFA) - induced acute inflammatory pain||Mouse - Rat|
|Complete Freund Adjuvant (CFA) - induced chronic inflammatory pain: monoarthritis model||Rat|
|Formalin paw (early phase)||Mouse - Rat|
|Formalin paw (late phase)||Mouse - Rat|
|Migraine model||Mouse - Rat|
|Mono-iodoacetate (MIA) - induced chronic inflammatory pain: osteoarthritis model||Rat|
|Mono-iodoacetate (MIA) - induced lower back pain||Rat|
Neuropathic pain is caused by damage or disease affecting the somatosensory nervous system and may be associated with abnormal pain from normally non-painful stimuli.
|Chemotherapy - induced periphera neuropathy (neurite outgrowth)||Peri.4U® neurons (Human)|
|Chemotherapy - induced neuropathic pain: Cisplatin||Rat|
|Chemotherapy - induced neuropathic pain: Vincristine model||Rat|
|Chronic Constrictive Injury - induced neuropathic pain: CCI/Bennett model||Mouse - Rat|
|Diabetic - induced neuropathy||Rat|
|Spinal Nerve Ligation - induced neuropathic pain: SNL/Chung model||Mouse - Rat|
Postoperative pain is an increase in background pain that occurs following a newly created wound.
|Brennan model post-operative pain||Rat – Guinea-pig|
Visceral pain occurs in the pelvis, abdomen, chest, or intestines as a result of insult, damage, or injury to internal organs or tissues.
|Acetic acid writhing||Mouse|
|Bezold-Jarish reflex (capsaicin) (anesthetized animal)||Rat|
|Colorectal distension (CRD) after 2,4,6 -trinitrobenzenesulfonicacid (TNBS) sensitization||Rat|
|Colorectal distension (CRD) after acetic acid sensitization||Rat|
|Dextran Sodium Sulfate (DSS) - induced colitis||Mouse|