PAIN

Porsolt offers models of acute and chronic pain and inflammation matching the needs of the industry and maintaining a recognized expertise, which addresses pain therapeutic endpoints and pain associated symptoms and side effects.

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Pain

PAIN DISEASE

Acute Pain

Acute nociceptive pain develops in response to a specific situation and tends to go away as the affected area heals.

IN VIVO MODELS
Cold-induced hyperalgesia Mouse - Rat
Hot Plate Mouse - Rat
Modified Hot Plate Mouse
Pain after local administration Mouse - Rat
Pinchmeter Mouse - Rat
Tail Flick Mouse - Rat

Inflammatory
Pain

Inflammatory pain can be defined as hypersensitivity in response to tissue damage and inflammation.

IN VIVO MODELS
Capsaicin paw Mouse - Rat
Carrageenan-induced acute inflammatory pain (reversal & prevention protocol) Rat
Complete Freund Adjuvant (CFA) - induced acute inflammatory pain Mouse - Rat
Complete Freund Adjuvant (CFA) - induced chronic inflammatory pain: monoarthritis model Rat
Formalin paw (early phase) Mouse - Rat
Formalin paw (late phase) Mouse - Rat
Migraine model Mouse - Rat
Mono-iodoacetate (MIA) - induced chronic inflammatory pain: osteoarthritis model Rat
Mono-iodoacetate (MIA) - induced lower back pain Rat

Neuropathic
Pain

Neuropathic pain is caused by damage or disease affecting the somatosensory nervous system and may be associated with abnormal pain from normally non-painful stimuli.

IN VITRO MODELS
Chemotherapy - induced periphera neuropathy (neurite outgrowth) Peri.4U® neurons (Human)
IN VIVO MODELS
Chemotherapy - induced neuropathic pain: Cisplatin Rat
Chemotherapy - induced neuropathic pain: Vincristine model Rat
Chronic Constrictive Injury - induced neuropathic pain: CCI/Bennett model Mouse - Rat
Diabetic - induced neuropathy Rat
Spinal Nerve Ligation - induced neuropathic pain: SNL/Chung model Mouse - Rat

Post-operative
pain

Postoperative pain is an increase in background pain that occurs following a newly created wound.

IN VIVO MODELS
Brennan model post-operative pain Rat – Guinea-pig

Visceral
pain

Visceral pain occurs in the pelvis, abdomen, chest, or intestines as a result of insult, damage, or injury to internal organs or tissues.

IN VIVO MODELS
Acetic acid writhing Mouse
Bezold-Jarish reflex (capsaicin) (anesthetized animal) Rat
Colorectal distension (CRD) after 2,4,6 -trinitrobenzenesulfonicacid (TNBS) sensitization Rat
Colorectal distension (CRD) after acetic acid sensitization Rat
Dextran Sodium Sulfate (DSS) - induced colitis Mouse
Parabenzoquinone writhing Mouse

Porsolt

Z.A. de Glatigné
53940 Le Genest-Saint-Isle, France
Telephone +33 2 43 69 36 07

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