MEDICAL DEVICES

Porsolt’s vast array of models and technical capabilities that have been acquired and validated over many years, enable us to provide testing services for Medical Devices that follow ISO and OECD guidelines and include in vitro and in vivo models for sensitization, toxicity and safety.

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medical devices

MEDICAL DEVICES

Cytoxicity

Cytotoxicity describes the property of a substance that being toxic to cells.

IN VITRO MODELS
MTT colorimetric cell viability assay L929 cells
Neutral Red colorimetric cell viability Assay 3T3 cells

Genotoxicity

Genotoxicity describes the property of a substance that damages the genetic information within a cell.

IN VITRO MODELS
Micronucleus assay TK6 cells
Postural hypotension (telemetry) Rat

Irritation

Cardiac activity, including electrical activity, is monitored under different conditions.

IN VITRO MODELS
Reconstituted human epidermis irritation assay Episkin
IN OVO MODELS
HET-CAM (Hen’s Egg Test Chorio Allantoic Membrane) - alternative to occular irritation assay Chicken egg
IN VIVO MODELS
Acute dermal irritation (topical application) Rabbit
Intradermal reactivity test (intracutaneous injection) Rabbit
Skin irritation test Rabbit

Skin Sensitization

Skin sensitization is the identification of chemicals able to elicit an allergic response.

IN VIVO MODELS
Guinea-pig Maximization Test (GPMT) Guinea-pig
Local Lymph Nodes Assay (LLNA) Mouse

Toxicity

Toxicity is the degree to which a chemical substance or a particular mixture of substances can cause damage.

IN OVO MODELS
Acute systemic toxicity (or repeated doses) alternative to embryotoxicity in mammals Chicken egg
IN VIVO MODELS
Acute systemic toxicity Mouse - Rat
Repeated doses systemic toxicity Mouse - Rat

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53940 Le Genest-Saint-Isle, France
Telephone +33 2 43 69 36 07

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