MEDICAL DEVICES
Porsolt’s vast array of models and technical capabilities that have been acquired and validated over many years, enable us to provide testing services for Medical Devices that follow ISO and OECD guidelines and include in vitro and in vivo models for sensitization, toxicity and safety.
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MEDICAL DEVICES

Cytoxicity
Cytotoxicity describes the property of a substance that being toxic to cells.
MTT colorimetric cell viability assay | L929 cells |
Neutral Red colorimetric cell viability Assay | 3T3 cells |

Genotoxicity
Genotoxicity describes the property of a substance that damages the genetic information within a cell.
Micronucleus assay | TK6 cells |
Postural hypotension (telemetry) | Rat |

Irritation
Cardiac activity, including electrical activity, is monitored under different conditions.
Reconstituted human epidermis irritation assay | Episkin |
HET-CAM (Hen’s Egg Test Chorio Allantoic Membrane) - alternative to occular irritation assay | Chicken egg |
Acute dermal irritation (topical application) | Rabbit |
Intradermal reactivity test (intracutaneous injection) | Rabbit |
Skin irritation test | Rabbit |

Skin Sensitization
Skin sensitization is the identification of chemicals able to elicit an allergic response.
Guinea-pig Maximization Test (GPMT) | Guinea-pig |
Local Lymph Nodes Assay (LLNA) | Mouse |

Toxicity
Toxicity is the degree to which a chemical substance or a particular mixture of substances can cause damage.
Acute systemic toxicity (or repeated doses) alternative to embryotoxicity in mammals | Chicken egg |
Acute systemic toxicity | Mouse - Rat |
Repeated doses systemic toxicity | Mouse - Rat |
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53940 Le Genest-Saint-Isle, France
Telephone +33 2 43 69 36 07
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