OBESITY & METABOLIC DISORDERS
Obesity and metabolism related disorders are key therapeutic areas that have attracted a global focus in recent times. Porsolt has a comprehensive range of models available for obesity, impaired glucose tolerance, and diabetes, to assist with the development of novel therapeutic agents and treatment and reduction of risk factors associated with metabolic diseases.
SCROLL
OBESITY & METABOLIC DISORDERS DISEASE
Diabetes
IN VITRO MODELS
IN VIVO MODELS
| Glucose stimulated insulin secretion | Rat insulinoma INS-1 cells |
| Chemically-induced animal models Alloxan-induced type 1diabetes single injection of alloxan |
Rat |
| HFD/STZ-induced Type 2 diabetes high fat diet and single injection of streptozotocin | Rat |
| Streptozotocin (STZ)-induced type 1 diabetes single injection of streptozotocin | Mouse - Rat |
| Genetic Animal Models Zucker Diabetic Fatty (ZDF) type 2 diabetes, glucose intolerance, hyperinsulinemia… |
Rat |
| Nutritional Animal Models Diet-induced obesity (DIO) special diets |
Mouse |
| Assessments Insulin tolerance test (ITT) |
Mouse – Rat |
| Intravenous glucose tolerance test (IVGTT) | Rat |
| Oral glucose tolerance test (OGTT) HOMA-IR, QUICKI and ISI calculation | Mouse – Rat |
Metabolic Disorders
IN VIVO MODELS
| Insulin tolerance test (ITT) | Mouse – Rat |
| Intravenous glucose tolerance test (IVGTT) | Rat |
| Oral glucose tolerance test (OGTT) | Mouse – Rat |
Obesity
IN VIVO MODELS
| Genetic Animal models Leptin-deficience ob/ob - db/db obesity, type 2 diabetes |
Mouse |
| Zucker Fatty obesity, hyperlipidemia… | Rat |
| Nutritional Animal Models Diet-induced obesity (DIO) special diets |
Mouse |
| Assessments Acute 24-hr feeding |
Rat |
| Fast-induced feeding (over 4 hours) | Mouse |
| Food/water intake and body weight gain (3-hr schedule-fed over10 days) | Rat |
| Food/water intake and body weight gain (over 28 days in pathologic animals) | Mouse - Rat |
BIOMARKER ASSAYS
| PLATFORM | BIOMARKER | SPECIES (SAMPLE) |
|---|---|---|
| ELISA | Pancreas activity (Insulin, glucagon) | Mouse, Rat (plasma) |
| Adipocytes (Adiponectin, leptin) | Mouse, Rat (plasma) | |
| Sexual hormone (testosteron) | Mouse, Rat (plasma, serum) | |
| GI hormones (Acyl ghrelin) | Mouse, Rat (plasma, serum) | |
| Biochemical | Lipid panel (HDL, LDL, FFA, TG, cholesterol…) | Mouse, Rat (plasma) |
| Liver function panel (ALAT, ASAT, ALP, bilirubin…) | Mouse, Rat (plasma) | |
| Renal function (creatinin, urea, electrolytes…) | Mouse, Rat (plasma, urine) | |
| Diabetes (HbA1c) | Rat (plasma) | |
| Pancreas activity (amylase, lipase) | Mouse, Rat (plasma, serum) | |
| CBA - ELISA - WB - IHC- PIHC - Fr - ICC - HTRF | Other targets upon request | Multiple species & biological specimens |
