OBESITY & METABOLIC DISORDERS

Obesity and metabolism related disorders are key therapeutic areas that have attracted a global focus in recent times. Porsolt has a comprehensive range of models available for obesity, impaired glucose tolerance, and diabetes, to assist with the development of novel therapeutic agents and treatment and reduction of risk factors associated with metabolic diseases.

OBESITY & METABOLIC DISORDERS CAPABILITIES

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Obesity and metabolic disorder

OBESITY & METABOLIC DISORDERS DISEASE

Diabetes

IN VITRO MODELS
Glucose stimulated insulin secretion Rat insulinoma INS-1 cells
IN VIVO MODELS
Chemically-induced animal models
Alloxan-induced type 1diabetes single injection of alloxan

Rat
HFD/STZ-induced Type 2 diabetes high fat diet and single injection of streptozotocin Rat
Streptozotocin (STZ)-induced type 1 diabetes single injection of streptozotocin Mouse - Rat
Genetic Animal Models
Zucker Diabetic Fatty (ZDF) type 2 diabetes, glucose intolerance, hyperinsulinemia…

Rat
Nutritional Animal Models
Diet-induced obesity (DIO) special diets

Mouse
Assessments
Insulin tolerance test (ITT)

Mouse – Rat
Intravenous glucose tolerance test (IVGTT) Rat
Oral glucose tolerance test (OGTT) HOMA-IR, QUICKI and ISI calculation Mouse – Rat

Metabolic Disorders

IN VIVO MODELS
Insulin tolerance test (ITT) Mouse – Rat
Intravenous glucose tolerance test (IVGTT) Rat
Oral glucose tolerance test (OGTT) Mouse – Rat

Obesity

IN VIVO MODELS
Genetic Animal models
Leptin-deficience ob/ob - db/db obesity, type 2 diabetes

Mouse
Zucker Fatty obesity, hyperlipidemia… Rat
Nutritional Animal Models
Diet-induced obesity (DIO) special diets

Mouse
Assessments
Acute 24-hr feeding

Rat
Fast-induced feeding (over 4 hours) Mouse
Food/water intake and body weight gain (3-hr schedule-fed over10 days) Rat
Food/water intake and body weight gain (over 28 days in pathologic animals) Mouse - Rat
BIOMARKER ASSAYS
PLATFORM BIOMARKER SPECIES (SAMPLE)
ELISA Pancreas activity (Insulin, glucagon) Mouse, Rat (plasma)
Adipocytes (Adiponectin, leptin) Mouse, Rat (plasma)
Sexual hormone (testosteron) Mouse, Rat (plasma, serum)
GI hormones (Acyl ghrelin) Mouse, Rat (plasma, serum)
Biochemical Lipid panel (HDL, LDL, FFA, TG, cholesterol…) Mouse, Rat (plasma)
Liver function panel (ALAT, ASAT, ALP, bilirubin…) Mouse, Rat (plasma)
Renal function (creatinin, urea, electrolytes…) Mouse, Rat (plasma, urine)
Diabetes (HbA1c) Rat (plasma)
Pancreas activity (amylase, lipase) Mouse, Rat (plasma, serum)
CBA - ELISA - WB - IHC- PIHC - Fr - ICC - HTRF Other targets upon request Multiple species & biological specimens

Porsolt

Z.A. de Glatigné
53940 Le Genest-Saint-Isle, France
Telephone +33 2 43 69 36 07

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