THROMBOSIS
Porsolt provides models for assessing the effects of compounds and potential therapies
on blood flow. These models can be used for investigating direct effects or
confounding and side effects of specific treatments on blood flow.
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THROMBOSIS
IN VITRO MODELS
IN VIVO MODELS
| Endothelial cell activation/ Drug-Induced Vascular Injury (DIVI) | HUVECs cells |
| Arterial thrombosis (FeCl2) | Rat |
| Arterio-venous shunt (silk thread model) | Rat |
| Bleeding time (anesthetized animal) | Rat |
| Venous thrombosis (FeCl2) | Rat |
BIOMARKER ASSAYS
| PLATFORM | BIOMARKER | SPECIES (SAMPLE) |
|---|---|---|
| Coagulation | APTT (Activated Partial Thrombin Time) | Multiple species |
| Prothrombin time | Multiple species | |
| Fibrinogen | Multiple species | |
| Hematology | Complete Blood Count: - Red blood cells: hemoglobin, hematocrit, mean cell volume, mean cell hemoglobin concentration, platelets - White blood cells: lymphocytes, neutrophils, eosinophils, basophils, monocytes | Multiple species |
| CBA - ELISA - WB - IHC-PIHC-Fr - ICC - HTRF | Other targets upon request | Multiple species & biological specimens |
