CARDIOVASCULAR SYSTEM
Porsolt has an extensive portfolio of cardiovascular procedures, ranging from standard cardiovascular telemetry studies for safety evaluation, to pathophysiological models for specific therapeutic areas. Porsolt also possesses considerable expertise with in vitro models, providing clients with a comprehensive assessment of all aspects of cardiovascular function.
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CARDIOVASCULAR SYSTEM DISEASE
Arrhythmias & Cardiac Toxicity
Cardiac Arrhythmias are a group of conditions in which the heartbeat is irregular and Cardiac Toxicity is the measurement of potential damage caused to the heart.
| Digoxin-induced ventricular arrhythmias (anesthetized animals) | Guinea-pig |
| Torsades de Pointes arrhythmias (modified Carlsson model) | Rabbit |
Automatic Nervous System
The autonomic nervous system regulates bodily functions, such as heart rate, and is monitored under different conditions.
| Postural hypotension (anesthetized animals) | Rat |
| Postural hypotension (telemetry) | Rat |
Cardiac Activity Recording
Cardiac activity, including electrical activity, is monitored under different conditions.
| Calcium assay | iPSC-derived cardiomyocytes: iCell2® |
| hCav1.2 channel | HEK 293 cells |
| hERG channel | HEK 293 cells |
| hERG trafficking | HEK 293 cells |
| hKir2.1 channel | HEK 293 cells |
| hKir2.1 trafficking | HEK 293 cells |
| hNav1.5 channel | HEK 293 cells |
| Inositol triphosphate receptor channel function | H9C2 cells |
| MEA assay | iPSC-derived cardiomyocytes |
| Papillary muscle | Guinea-pig |
| Purkinje fiber | Rabbit – Dog |
| Spontaneously beating right atrium | Guinea-pig – Rabbit |
| Stimulated left atrium | Guinea-pig – Rabbit |
Hemodynamics
The dynamics of blood flow in the circulatory system, and adjustments to differing conditions.
ANESTHETIZED ANIMALS
| Arterial blood pressure, heart rate and ECG | Rat – Guinea-pig |
| Bezold - Jarish reflex (capsaicin or 5-HT) | Rat - Rabbit |
| Regional blood flow | Rat |
| Systemic, cardiac, renal and pulmonary hemodynamics | Dog – Mini-pig |
| Systemic and cardiac hemodynamics(cardiac denervated animal) | Dog |
CONCIOUS ANIMALS (TELEMETRY)
| Arterial blood pressure, heart rate ± ECG | Mouse – Rat – Dog - Guinea-pig – Mini-pig |
| Left ventricular pressure, heart rate ± ECG | Rat – Dog |
| Pulmonary arterial blood pressure, heart rate and ECG | Dog |
| Right ventricular pressure and heart rate | Rat |
Hypertension
Hypertension is when the blood pressure in the arteries is persistently elevated.
| Endothelial cell activation/Drug-Induced Vascular Injury | HUVECs |
| 5/6 nephrectomy | rat |
| Arterial blood pressure and heart rate | SH Rat |
| Arterial blood pressure and heart rate (telemetry) | SH rat |
| Bile duct ligation-induced portal vein hypertension (telemetry) | Rat |
| Chronic (2K1C) Goldblatt hypertension (high renin model) | Rat |
| Chronic DOCA - salt hypertension(low renin model) | Rat |
| Monocrotaline-induced pulmonary hypertension (anesthetized animals) | Rat |
| Monocrotaline-induced pulmonary hypertension (telemetry) | Rat |
Isolated Vascular Beds
Tissues are isolated from smooth muscles of the cardiovascular, respiratory, gastrointestinal or urogenital tracts for testing the effects of substances.
| Isolated mesenteric artery | Dog |
| Isolated saphenous vein | Rabbit – Dog |
| Isolated thoracic aorta | Rat – Rabbit |
