CARDIOVASCULAR SYSTEM

Porsolt has an extensive portfolio of cardiovascular procedures, ranging from standard cardiovascular telemetry studies for safety evaluation, to pathophysiological models for specific therapeutic areas. Porsolt also possesses considerable expertise with in vitro models, providing clients with a comprehensive assessment of all aspects of cardiovascular function.

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CARDIOVASCULAR SYSTEM DISEASE

Arrhythmias & Cardiac Toxicity

Arrhythmias & Cardiac Toxicity

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Cardiac Arrhythmias are a group of conditions in which the heartbeat is irregular and Cardiac Toxicity is the measurement of potential damage caused to the heart.

IN VIVO MODELS
Digoxin-induced ventricular arrhythmias (anesthetized animals) Guinea-pig
Torsades de Pointes arrhythmias (modified Carlsson model) Rabbit

Automatic Nervous System

The autonomic nervous system regulates bodily functions, such as heart rate, and is monitored under different conditions.

IN VIVO MODELS
Postural hypotension (anesthetized animals) Rat
Postural hypotension (telemetry) Rat

Cardiac Activity Recording

Cardiac Activity Recording

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Cardiac activity, including electrical activity, is monitored under different conditions.

IN VITRO MODELS
Calcium assay iPSC-derived cardiomyocytes: iCell2®
hCav1.2 channel HEK 293 cells
hERG channel HEK 293 cells
hERG trafficking HEK 293 cells
hKir2.1 channel HEK 293 cells
hKir2.1 trafficking HEK 293 cells
hNav1.5 channel HEK 293 cells
Inositol triphosphate receptor channel function H9C2 cells
MEA assay iPSC-derived cardiomyocytes
EX VIVO MODELS
Papillary muscle Guinea-pig
Purkinje fiber Rabbit – Dog
Spontaneously beating right atrium Guinea-pig – Rabbit
Stimulated left atrium Guinea-pig – Rabbit

Hemodynamics

The dynamics of blood flow in the circulatory system, and adjustments to differing conditions.

IN VIVO MODELS

ANESTHETIZED ANIMALS

Arterial blood pressure, heart rate and ECG Rat – Guinea-pig
Bezold - Jarish reflex (capsaicin or 5-HT) Rat - Rabbit
Regional blood flow Rat
Systemic, cardiac, renal and pulmonary hemodynamics Dog – Mini-pig
Systemic and cardiac hemodynamics(cardiac denervated animal) Dog

CONCIOUS ANIMALS (TELEMETRY)

Arterial blood pressure, heart rate ± ECG Mouse – Rat – Dog - Guinea-pig – Mini-pig
Left ventricular pressure, heart rate ± ECG Rat – Dog
Pulmonary arterial blood pressure, heart rate and ECG Dog
Right ventricular pressure and heart rate Rat

Hypertension

Hypertension is when the blood pressure in the arteries is persistently elevated.

IN VITRO MODELS
Endothelial cell activation/Drug-Induced Vascular Injury HUVECs
IN VIVO MODELS
5/6 nephrectomy rat
Arterial blood pressure and heart rate SH Rat
Arterial blood pressure and heart rate (telemetry) SH rat
Bile duct ligation-induced portal vein hypertension (telemetry) Rat
Chronic (2K1C) Goldblatt hypertension (high renin model) Rat
Chronic DOCA - salt hypertension(low renin model) Rat
Monocrotaline-induced pulmonary hypertension (anesthetized animals) Rat
Monocrotaline-induced pulmonary hypertension (telemetry) Rat

Isolated Vascular Beds

Tissues are isolated from smooth muscles of the cardiovascular, respiratory, gastrointestinal or urogenital tracts for testing the effects of substances.

IN VIVO MODELS
Isolated mesenteric artery Dog
Isolated saphenous vein Rabbit – Dog
Isolated thoracic aorta Rat – Rabbit

Porsolt

Z.A. de Glatigné
53940 Le Genest-Saint-Isle, France
Telephone +33 2 43 69 36 07

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