News & Publications

On this page, you can find our publications in different disease areas and all the latest news and updates related to Porsolt.

gastro-intestinal system

Nausea and vomiting are common side effects of cancer chemotherapy. The ferret is a highly appropriate animal species to evaluate both early …

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The present paper will suggest, on the basis of experimental evidence, that several non-human primate (NHP) procedures can be uniquely useful and …

Central Nervous System

Repeated haloperidol treatment administered to nonhuman primates (NHPs) over several months or even years leads to the gradual appearance of drug-induced dystonic …

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Safety pharmacology entails the assessment of the potential risks of novel pharmaceuticals for human use. As detailed in the ICH S7A guidelines, …

urogenital system

Hydroxypropyl-β-cyclodextrin (HPβCD) is a complexation agent used to enhance drug solubilization and formulation stability. Although its toxicity is well characterized, its cardiovascular …

Cardio Vascular System

 In the current ICH S7B guideline, in vitro evaluation of proarrhythmic liability is limited to the risk of QT interval prolongation, whilst …

Cardio Vascular System

In vitro electrophysiological safety studies have become an integral part of the drug development process since, in many instances, compound-induced QT prolongation …

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Medicinal products that prolong cardiac repolarization unintentionally, as assessed in terms of prolongation of the QT interval of the electrocardiogram, may trigger …

Central Nervous System

Preclinical testing requires rapid and reliable evaluation of the main in vivo effects of novel test substances usually in rodents. Nevertheless, the …

Central Nervous System

Nonclinical assessment of drug abuse and dependence is the subject of several recent regulatory guidelines, which are generally aligned on the methods …

Porsolt

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53940 Le Genest-Saint-Isle, France
Telephone +33 2 43 69 36 07

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