You searched for Cognition Aging

Cognition and Dementia in Brain Research

Porsolt continues its strong research record with a recently published paper in “Brain Research” on age-related cognitive deficits in mice.

CENTRAL NERVOUS SYSTEM

CENTRAL NERVOUS SYSTEM Porsolt offers models in all areas of psychopharmacology, epilepsy, sleep-wake, and neurodegenerative disorders. We are uniquely placed to offer a full range of CNS efficacy and safety…

Synergistic enhancing-memory effect of donepezil and S 47445, an AMPA positive allosteric modulator, in middle-aged and aged mice

Synergistic enhancing-memory effect of donepezil and S 47445, an AMPA positive allosteric modulator, in middle-aged and aged mice. PORSOLT_Synergistic-enhancing-memory-effect-of-donepezil-and-S-47445-an-AMPA-positive-allosteric-modulator-in-middle-aged-and-aged-mice.Download Keywords: AMPA receptors; Acetylcholine; Cognition; Aging; Alzheimer disease; Amnesia; Glutamate.

HiPSC Parkinson’s disease Model

Parkinson's disease (PD) affects 1-2 per 1000 of the general population. PD prevalence is increasing with age and PD affects 1% of the population above 60 years. Most symptoms are…

CNS safety pharmacology: A focus on cognitive functions

The guidelines from different agencies do not include studies on cognitive functions as part of safety pharmacology. This is unfortunate as it seems important to verify that drugs entering into…