Coughing models

Coughing is one of the most common symptoms associated with respiratory diseases such as asthma, chronic bronchitis, and pulmonary fibrosis.
Porsolt has established the citric acid induced cough model in guinea-pigs and the tracheal phenol red output model in mice that can be used for testing different classes of treatment, including mucolytics, expectorants, antitussives, bronchodilators, and glucocorticoids. 

The following data shows the effects of Codeine, an antitussive for repressing cough, which reduces the number of coughs, the tidal volume, and the minute volume in the guinea-pig. Ambroxol and Guaifenesin (expectorants that thin the mucus layer) can also be seen to increase the phenol red secretion by mucous cells of submucosal glands and goblet cells of the surface epithelium in airways.

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