Nonclinical assessment of drug abuse and dependence is the subject of several recent regulatory guidelines, which are generally aligned on the methods to be employed. The most direct approach to…
Preclinical assessment of drug abuse and dependence has been the subject of several recent regulatory guidelines. Both the European and US authorities recommend a tiered approach and are generally aligned…
SAFETY REGULATORY PACKAGE Porsolt’s broad expertise and years of preclinical pharmacology experience makes us the ideal partner to conduct your GLP Safety Pharmacology experiments. Porsolt offers safety studies in both…
CENTRAL NERVOUS SYSTEM Porsolt offers models in all areas of psychopharmacology, epilepsy, sleep-wake, and neurodegenerative disorders. We are uniquely placed to offer a full range of CNS efficacy and safety…
OBE022, an Oral and Selective Prostaglandin F2α Receptor Antagonist as an Effective and Safe Modality for the Treatment of Preterm Labor. PORSOLT_OBE022-an-Oral-and-Selective-Prostaglandin-F2945-Receptor-Antagonist-as-an-Effective-and-Safe-Modality-for-the-Treatment-of-Preterm-Labor.Download keywords : Drug Discovery, Translational Medicine, Drug…
Stimulant drugs produce reward but also activate stress-responsive systems. The corticotropin-releasing factor (CRF) and the related hypothalamus-pituitary-adrenal (HPA) axis stress-responsive systems are activated by stimulant drugs. PORSOLT_CRF1-receptor-deficiency-increases-cocaine-reward.Download Keywords: Cocaine; Corticotropin-releasing…
At present there is no satisfactory treatment against relapse of drug-seeking behavior. Relapse can be modeled in laboratory animals using reinstatement procedures, whereby previously extinguished self-administration for a drug is…