Non-human primates – translational models for predicting antipsychotic-induced movement disorders

Repeated haloperidol treatment administered to nonhuman primates (NHPs) over several months or even years leads to the gradual appearance of drug-induced dystonic reactions in the orofacial region (mouth opening, tongue protrusion or retraction, bar biting) and in the whole body (writhing of the limbs and trunk, bar grasping).

 
keywords : Psychiatric diseases, NPH, antipsychotics