Models of cardiovascular disease : measurement antihypertensive activity in the conscious rat (SHR, DOCA-Salt, and the Goldblatt hypertension models).

The protocols described in this unit are used to assess the effects of new chemical entities on hypertension in conscious rats. In the spontaneously hypertensive rat (SHR) model, the results obtained with the reference compounds clonidine, prazosin, propranolol, and captopril are provided for illustration. All compounds demonstrate antihypertensive activity, with captopril and prazosin being the least and the most active, respectively.