In vitro safety cardiovascular pharmacology studies – impact of formulation preparation and analysis

Collection of formulation samples is required for GLP in vitro studies to check the exposure of the test system and allow reliable determinations of safety margins. In vitro studies conducted in-house were investigated to evaluate problems of solubility, stability and adsorption of the formulations.

Keywords: Adsorption; Formulation analysis; Purkinje; Solubility; Stability; hERG.