Automated analysis of delayed emesis in the telemetered ferret detection of synergistic effects of aprepitant and ondansetron

Nausea and vomiting are common side effects of cancer chemotherapy. We have previously described a model in the ferret where delayed emesis can be measured automatically using telemetry. This study was designed to examine the sensitivity of this automated emesis model for detecting moderate and/or additive pharmacological effects by investigating low-dose effects of aprepitant alone or in combination with ondansetron.

Keywords: aprepitant; chemotherapy; cisplatin; combined therapy; delayed emesis; telemetered ferret.