Dependence Potential

Identifying abuse and dependence liability is an important issue for CNS safety pharmacology.  Regulatory bodies in the US and Europe are in the process of developing standard guidelines, based on looking for similarities with known drugs of abuse.

At Porsolt , we provide fully GLP compliant models for evaluating drug dependence and liability:

> Spontaneous withdrawal effects, including telemetry assessment

> Precipitated withdrawal (naloxone, flumazenil)

> Place preference

> Drug discrimination

> Self-administration

Learn more

Recent Porsolt publications: