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UROGENITAL SYSTEM

Porsolt offers a range of models that address complications specific to, or associated with, the urogenital system, including the assessment of renal function, bladder function, and the genital system.

Bladder function

Normal bladder

Our models:

> Isovolumetric rhythmic bladder contractions in in anesthetized female rats

> Bladder function and micturition reflex in anesthetized female rats (continuous bladder infusion)

> Bladder function and micturition reflex in conscious female dogs (continuous bladder infusion)

Isovolumetric rhythmic bladder contraction in anesthetized female rats
** = p < 0.01, Student’s test (oxybutynin versus vehicle, n=6 in each group)
Oxybutynin reduced the amplitude of contractions but had no effect on the contraction rate

Overactive bladder (models for urge incontinence)

Example of arterial blood pressure and bladder pressure recording (cystometry)

> Transvesical cystometry in anesthetized female rats

> Transvesical cystometry in anesthetized male dogs

> Isolated bladder strip

Bladder function

Normal bladder

Overactive bladder (models for urge incontinence)

Porsolt

WORLDWIDE PRESENCE