PREDICTIVE TOXICITY

PREDICTIVE TOXICITY

Liver, heart, kidney and brain drug-induced toxicities currently account for more than 70% of drug attrition and drug withdrawal. Porsolt together with Fluofarma has developed a range of organ-specific cell-based assays to better predict the toxicity potential of drug candidates.

Predictive in vivo models

Acute toxicity Rat - Mouse - Dog - Mini-pig TOX 11

Preliminary chronic toxicity

Rat - Mouse TOX 12
pK Multiple species TOX 13

in vitro models

Prior to in vivo studies, based on highly predictive cellular models, i.e. primary cell cultures, Fluofarma our affiliate,  performs functional toxicity assays and offers to investigate the signaling pathways involved in detoxification and oxidative stress induced by the drug compound.