PHARMACOKINETICS

PHARMACOKINETICS

Pharmacokinetic (pK) studies are a key component of drug development programs, that help determine the appropriate modes of administration, dose ranges, and treatment timing. Porsolt has many years of experience, performing pK studies, as standalone services, or as part of larger studies involving established models. Our varied capabilities and expertise enable us to use multiple routes of administration, in different species, and collect a variety of tissues for analysis.

Specialized routes of administration

Oral

Intravenous: infusion/bolus

Inhalation

Subcutaneous

Intraplantar

Intracranial

Intracolonic

Intraperitoneal

Sample collection

Multiple tissues (brain, liver, spleen...)

Blood, plasma

Venous catheter

CSF,…

Clinical Chemistry

➤ PARAMETERS MEASURED ON SERUM/PLASMA SAMPLES
Calcium (total)
Magnesium, Phosphorus, Sodium, Potassium
Chloride/Triglycerides/Creatinine
Total Bilirubin
AST (Aspartate Aminotransferase)/ALP (Alkaline Phosphatase)/ALT (Alanine Aminotransferase)
GGT (Gamma Glutamyl Transferase)
Cholesterol/HDL cholesterol/LDL cholesterol/Glucose
NEFA (Non Esterified Fatty Acids)
Total proteins/Urea/Albumin
Amylase (pancreatic)/Lipase

➤ PARAMETERS MEASURED ON URINARY SAMPLES
Urea
Sodium, Potassium, Chloride
Albumin (microalbumin)/Total proteins/Semi-quantitative parameters

➤ PARAMETERS MEASURED ON CELL CULTURE SUP.
LDH (lactate deshydrogenase)

➤ PARAMETERS MEASURED ON TOTAL BLOOD
HbA1c (glycated hemoglobin)

 

Coagulation

➤ PARAMETERS MEASURED ON PLASMA SAMPLES
APTT (Activated Partial Thrombin Time)
Prothrombin Time/Fibrinogen

Hematology

➤ Complete blood count including red blood cell, hemoglobin,hematocrit, mean cell volume, mean cell hemoglobin, mean cell hemoglobin concentration, platelets, white blood cell, neutrophils, lymphocytes, monocytes, eosinophils, basophils.