Visceral pain

PAIN

Porsolt offers models of acute and chronic pain and inflammation matching the needs of the industry and maintaining a recognized expertise, which addresses pain therapeutic endpoints and pain associated symptoms and side effects.

Visceral pain

Writhing in the mouse

REAGENT AGENTS REFERENCE ROUTE POSITIVE EFFECTS
Acetic acid




 Morphine i.p., p.o., s.c., i.v. yes
Tramadol p.o. yes
Duloxetine p.o. NS
Gabapentin

i.p.

 NS
Duloxetine i.p. yes

Parabenzo-quinone		 Tramadol p.o. yes
Morphine

i.p.

 yes

> Acetic acid-induced or parabenzoquinone–induced writhing in the mouse

Animals are injected i.p. with acetic acid or parabenzoquinone. The number of writhes is counted for 10 minutes, beginning 5 minutes after the injection of reagent.

Abnominal cramps in the rat

REAGENT AGENT REFERENCE ROUTE POSITIVE EFFECTS
     Acetic acid    

U -50,488H p.o. yes
Morphine p.o. yes
Amitriptyline p.o. yes
Tianeptine p.o. yes
TNBS

 U -50,488H p.o. yes
Celecoxib p.o. yes
Phloroglucinol p.o. yes

Other models of visceral pain in rodents: colonic irritation / inflammation and distension in the rat (acid acetic model)