PAIN
Porsolt offers models of acute and chronic pain and inflammation matching the needs of the industry and maintaining a recognized expertise, which addresses pain therapeutic endpoints and pain associated symptoms and side effects.
REAGENT AGENTS | REFERENCE | ROUTE | POSITIVE EFFECTS |
Acetic acid |
Morphine | i.p., p.o., s.c., i.v. | yes |
Tramadol | p.o. | yes | |
Duloxetine | p.o. | NS | |
Gabapentin |
i.p. |
NS | |
Duloxetine | i.p. | yes | |
Parabenzo-quinone |
Tramadol | p.o. | yes |
Morphine |
i.p. |
yes |
> Acetic acid-induced or parabenzoquinone–induced writhing in the mouse
Animals are injected i.p. with acetic acid or parabenzoquinone. The number of writhes is counted for 10 minutes, beginning 5 minutes after the injection of reagent.
REAGENT AGENT | REFERENCE | ROUTE | POSITIVE EFFECTS |
Acetic acid |
U -50,488H | p.o. | yes |
Morphine | p.o. | yes | |
Amitriptyline | p.o. | yes | |
Tianeptine | p.o. | yes | |
TNBS |
U -50,488H | p.o. | yes |
Celecoxib | p.o. | yes | |
Phloroglucinol | p.o. | yes |