PAIN
Porsolt offers models of acute and chronic pain and inflammation matching the needs of the industry and maintaining a recognized expertise, which addresses pain therapeutic endpoints and pain associated symptoms and side effects.
Reversal (therapeutic) |
Mouse | Paw weight | Aspirin | p.o. | yes |
Water displacement (in development) |
Aspirin | p.o., i.p. | yes | ||
Rat |
Water displacement |
Paracetamol | i.p. | yes | |
Aspirin | p.o. | yes | |||
Prevention (prophylactic) |
Rat |
Water displacement |
Aspirin | p.o. | yes |
Indomethacin | p.o. | yes | |||
Celecoxib | i.p. | yes | |||
Protocols | Species | Parameters |
Substances |
Routes | Positive effects |
Carrageenan | s.c. | yes |
Zymosan | s.c. | yes |
LPS | s.c. | NS |
Substances | Routes | Positive effects |
Mice receive a single topical application of TPA.
Ear thickness is measured using a micrometer gauge before TPA application and then 4 and 6 hours after.
> Yeast hyperthermia
> Lipopolysaccharide (LPS) septic shock