PAIN
Porsolt offers models of acute and chronic pain and inflammation matching the needs of the industry and maintaining a recognized expertise, which addresses pain therapeutic endpoints and pain associated symptoms and side effects.
Acute pain
PINCHMETER - HOT PLATE - TAIL FLICK
Several acute pain assays measuring responses to tactile and thermal stimulations are available in rodents. Hot plate and tail-flick tests evaluate thermal hyperalgesia while the pinchmeter test (alternative method to Randall and Selitto test) is used to assess tactile hyperalgesia.
| Species | Substance | Route | Positive effect |
| STANDARD HOT PLATE | |||
| Mouse/Rat | Morphine | p.o., i.p., s.c., i.v. | yes |
| Mouse/Rat | Tramadol | p.o., i.p. | yes |
| Mouse | Aspirin | i.p. | NS |
| Rat | Lidocaine | Sciatic Nerve Block | yes |
| MODIFIED HOT PLATE | |||
| Mouse/Rat | Paracetamol | p.o., i.p. | yes |
| Mouse | Morphine | i.v. | yes |
| Mouse | Paracetamol | i.p. | NS (200 mg/kg) |
| PINCHMETER | |||
| Mouse/Rat | Morphine | i.p. | yes |
| Rat | Tramadol | p.o. | NS |
| Rat | Lidocaïne | Sciatic Nerve Block | yes |
| TAIL FLICK | |||
| Mouse/Rat | Morphine | p.o., i.p., s.c., i.v.*, i.t.* | yes |
| Mouse/Rat | Tramadol | p.o., i.p. | yes |
| Mouse/Rat | Paracetamol | i.p., p.o. | yes |
| Rat | Fentanyl | s.c. | yes |
| Mouse | Codeine | p.o. | yes |
* In the mouse only
Pinchmeter test: effects of morphine
Porsolt
Z.A. de Glatigné
53940 Le Genest-Saint-Isle, France
Telephone +33 2 43 69 36 07
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