PAIN
Porsolt offers models of acute and chronic pain and inflammation matching the needs of the industry and maintaining a recognized expertise, which addresses pain therapeutic endpoints and pain associated symptoms and side effects.
ACUTE PAIN
| IN VIVO | ||
| Hot plate | Mouse - Rat | PI 1 |
| Modified hot plate | Mouse | PI 28 |
| Tail flick | Mouse - Rat | PI 2 |
| Pinchmeter | Mouse - Rat | PI 22 |
| Cold-induced hyperalgesia | Rat | PI 36 |
| Acute pain - Learn More | ||
NEUROPATHIC PAIN
| IN VITRO | ||
| Chemotherapy-induced peripheral neuropathy (neurite outgrowth) | Peri.4U® neurons | PF 10.48 |
| IN VIVO | ||
| Chronic Contrictive Injury - induced neuropathic pain: CCI/Bennett model | Rat - Mouse | PI 12 |
| Spinal Nerve Ligation - induced neuropathic pain: SNL/Chung model | Rat | PI 13 |
| Chemotherapy - neuropathic pain: Vincristine model | Rat | PI 21 |
| Neuropathic pain - Learn More | ||
INFLAMMATORY PAIN
| IN VIVO | ||
| Capsaicin paw | Mouse - Rat | PI 30 |
| Formalin paw (early phase) | Mouse - Rat | PI 7 |
| Formalin paw (late phase) | Mouse - Rat | PI 8 |
| Carrageenan-induced acute inflammatory pain (reversal & prevention protocol) | Rat | PI 14 |
| Complete Freund Adjuvant (CFA) - induced acute inflammatory pain | Rat | PI 20 |
| Complete Freund Adjuvant (CFA) - induced chronic inflammatory pain: monoarthritis model | Rat | PI 15 |
| Mono-iodoacetate (MIA) - induced chronic inflammatory pain: osteoarthritis model | Rat | PI 19 |
| Inflammatory pain - Learn More | ||
POST-OPERATIVE PAIN
| IN VIVO | ||
| Brennan model | Rat | PI 16 |
| Post-operative pain - Learn More | ||
VISCERAL PAIN
| IN VIVO | ||
| Acetic acid writhing | Mouse | PI 6 |
| Parabenzoquinone writhing | Mouse | PI 27 |
| Colorectal distension (CRD) after acetic acid sensitization | Rat | GI 13 |
| Colorectal distension (CRD) after 2,4,6-trinitrobenzenesulfonic acid (TNBS) sensitization | Rat | GI 14 |
| Bezold-Jarish reflex (capsaicin) (anesthetized animal) | Rat | CV 1.12 |
| Visceral pain - Learn More | ||
INFLAMMATION
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IN VITRO |
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Immunology cell subsets immunophenotyping and immune cell response Cell physiology and metabolism Cell signaling |
Multiple cellular models |
> Learn more |
| IN VIVO | ||
| Air pouch | Mouse | PI 24 |
| Carrageenan-induced edema evaluation (reversal protocol) | Mouse - Rat | PI 9 |
| Carrageenan-induced paw edema (preventive protocol) | Rat | PI 17 |
| Carrageenan-induced abscess | Rat | PI 10 |
| 12-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema | Mouse | PI 18 |
| Arachidomic acid-induced ear edema | Mouse | PI 31 |
| Yeast-induced hyperthermia | Mouse | PI 11 |
| Lipopolysaccharide (LPS)-induced septic shock | Mouse | PI 29 |
| Lipopolysaccharide (LPS)-induced neutrophilia | Ferret | PI 33 |
| Inflammation - Learn More | ||
Porsolt
Z.A. de Glatigné
53940 Le Genest-Saint-Isle, France
Telephone +33 2 43 69 36 07
Contact us
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