Acute pain

PAIN & INFLAMMATION

Porsolt offers models of acute and chronic pain and inflammation matching the needs of the industry and maintaining a recognized expertise, which addresses pain therapeutic endpoints and pain associated symptoms and side effects.

Acute pain

PINCHMETER - HOT PLATE - TAIL FLICK

Several acute pain assays measuring responses to tactile and thermal stimulations are available in rodents. Hot plate and tail-flick tests evaluate thermal hyperalgesia while the pinchmeter test (alternative method to Randall and Selitto test) is used to assess tactile hyperalgesia.

Species Substance Route Positive effect
STANDARD HOT PLATE
Mouse/Rat Morphine p.o., i.p., s.c., i.v. yes
Mouse/Rat Tramadol p.o., i.p. yes
Mouse   Aspirin  i.p. NS
Rat   Lidocaine      Sciatic Nerve Block               yes         
MODIFIED HOT PLATE
Mouse/Rat Paracetamol              p.o., i.p.            yes
Mouse Morphine i.v. yes
Mouse Paracetamol  i.p. NS (200 mg/kg)
PINCHMETER
Mouse/Rat Morphine i.p.           yes         
Rat Tramadol p.o. NS
Rat    Lidocaïne      Sciatic Nerve Block    yes
TAIL FLICK
Mouse/Rat Morphine p.o., i.p., s.c., i.v.*, i.t.*           yes         
Mouse/Rat Tramadol p.o., i.p. yes
Mouse/Rat Paracetamol i.p., p.o. yes
Rat Fentanyl s.c. yes
Mouse Codeine p.o. yes

* In the mouse only

Pinchmeter test: effects of morphine