PAIN & INFLAMMATION

PAIN & INFLAMMATION

Porsolt offers models of acute and chronic pain and inflammation matching the needs of the industry and maintaining a recognized expertise, which addresses pain therapeutic endpoints and pain associated symptoms and side effects.

ACUTE PAIN

Hot plate Mouse - Rat PI 1
Modified hot plate Mouse   PI 28
Tail flick Mouse - Rat PI 2
Pinchmeter Mouse - Rat PI 22
Cold-induced hyperalgesia Rat PI 36
Acute pain - Learn More

NEUROPATHIC PAIN

NEW Chronic Contrictive Injury - induced neuropathic pain: CCI/Bennett model Rat - Mouse PI 12
Spinal Nerve Ligation - induced neuropathic pain: SNL/Chung model Rat  PI 13
Chemotherapy - neuropathic pain: Vincristine model Rat PI 21
Neuropathic pain - Learn More

INFLAMMATORY PAIN

Capsaicin paw Mouse - Rat PI 30
Formalin paw (early phase) Mouse - Rat PI 7
Formalin paw (late phase) Mouse - Rat PI 8
Carrageenan-induced acute inflammatory pain (reversal & prevention protocol) Rat PI 14
Complete Freund Adjuvant (CFA) - induced acute inflammatory pain Rat PI 20
Complete Freund Adjuvant (CFA) - induced chronic inflammatory pain: monoarthritis model Rat PI 15
Mono-iodoacetate (MIA) - induced chronic inflammatory pain: osteoarthritis model Rat PI 19
Inflammatory pain - Learn More

POST-OPERATIVE PAIN

Brennan model Rat PI 16
Post-operative pain - Learn More

VISCERAL PAIN

Acetic acid writhing Mouse PI 6
Parabenzoquinone writhing Mouse PI 27
Colorectal distension (CRD) after acetic acid sensitization Rat GI 13
Colorectal distension (CRD) after 2,4,6-trinitrobenzenesulfonic acid (TNBS) sensitization Rat GI 14
Bezold-Jarish reflex (capsaicin) (anesthetized animal) Rat CV 1.12
Visceral pain - Learn More

INFLAMMATION

IN VITRO

Immunology cell subsets immunophenotyping and immune cell response

Cell physiology and metabolism

Cell signaling

Multiple cellular models

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Air pouch Mouse PI 24
Carrageenan-induced edema evaluation (reversal protocol) Mouse - Rat PI 9
Carrageenan-induced paw edema (preventive protocol) Rat PI 17
Carrageenan-induced abscess Rat PI 10
12-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema Mouse PI 18
Arachidomic acid-induced ear edema Mouse PI 31
Yeast-induced hyperthermia Mouse PI 11
Lipopolysaccharide (LPS)-induced septic shock Mouse PI 29
Lipopolysaccharide (LPS)-induced neutrophilia Ferret PI 33
Inflammation - Learn More