Obesity

OBESITY & METABOLIC DISORDERS

Obesity and metabolism related disorders are key therapeutic areas that have attracted global attention over recent years. Porsolt has in place a comprehensive range of models for obesity, impaired glucose tolerance, and diabetes to assist with the development of novel therapeutic agents for the treatment and reduction of risk factors associated with metabolic diseases.

Obesity

Acute feeding models (mouse or rat)

These studies are ideal for screening the effects of a test substance on food consumption in mice or rats and have a quick turn around time. Additional parameters to be measured can include glucose, insulin, lipid profile and body fat mass (*).
(*) DEXA Scan in collaboration with Atlantic Bone Screen (Nantes, France)

Effects of sibutramine on food intake in C57BL6 mice (after overnight fasting)

Effects of rimonabant and sibutramine on food intake in SD rats (reverse phase light-dark cycle)

Chronic feeding models

Models of chronic feeding measuring body weight and food intake.

• 3-hr schedule feeding for 10 days in normal rats:

Effects of sibutramine on body weight and food intake in Wistar rats

• Continuous feeding for 28 days in Zucker fa/fa rats:

Effects of sibutramine on body weight and food intake in Zucker fa/ fa rats