Metabolic disorders

OBESITY & METABOLIC DISORDERS

Obesity and metabolism related disorders are key therapeutic areas that have attracted global attention over recent years. Porsolt has in place a comprehensive range of models for obesity, impaired glucose tolerance, and diabetes to assist with the development of novel therapeutic agents for the treatment and reduction of risk factors associated with metabolic diseases.

Metabolic disorders

Porsolt offers several rodent models for screening and testing the therapeutic potential of novel drugs for the treatment and the reduction of risk factors associated with metabolic diseases.

Animal models:

ob/ob mice, db/db mice, Zucker fatty fa/fa rats, Zucker Diabetic Fatty (ZDF) rats, Diet-induced obese (DIO) mice, Streptozotocin (STZ)-induced diabetes, Alloxan-induced diabetes …

Assessments:

Body weight, Food/caloric intake, Glucose/Insulin levels, Glucose/Insulin tolerance tests, Metabolic biomarkers,…

Portfolio

Genetic animal models
ob/ob mice 

Leptin-deficient mouse: obesity, type 2 diabetes

db/db mice

Leptin-deficient mouse: obesity, type 2 diabetes 

Zucker Fatty rats

 Obesity, hyperlipidemia… 
Zucker Diabetic Fatty (ZDF) rats Type 2 diabetes, glucose intolerance, hyperinsulinemia...

Assessments
Oral glucose tolerance test (OGTT) (in normal or pathologic animals) Mouse - Rat MET 12
Intravenous glucose tolerance test (IVGTT) Rat MET 1
Insulin tolerance test (ITT) Mouse - Rat MET 2

and  Body weight gain | Food, water or caloric intake

Biochemistry

HOMA-IR, QUICKI and ISI calculation

Lipid panel (Triglycerides, Cholesterol, Free Fatty Acids,…)

Liver function panel (AminoTransferases, Alkaline Phosphatase, Bilirubin)

Renal function panel (Creatinine, Electrolytes,…)

Metabolic biomarkers (Adiponectin, Leptin, Glucagon,…)

Organ & Tissue collection

Glucose tolerance test (OGTT or IVGTT) in normal mice or rats

Measurement of fasting blood glucose levels before and after glucose challenge in Wistar or Sprague Dawley rats, or C57BL6 mice after overnight fasting. Results can be available within two weeks of receipt of the test substance.

OGTT in rats: effects of metformin

IVGTT in rats: effects of clozapine

OGTT in mice: effects of sitagliptin

Glucose tolerance test (OGTT or IVGTT) in pathological mice or rats

Measurements of fasting blood glucose and plasma insulin levels before and after glucose challenge in ZDF rats.

OGTT in ZDF rats : effects of metformin and rosiglitazone

> Additional models: db-db mice, ob-ob mice, DIO mice and Zücker fa/fa rats.

> References: Metformin, Glibenclamide, Sitagliptin