Porsolt's vast array of models and technical capabilities that have been acquired and validated over many years, enable us to provide testing services for Medical Devices that follow ISO and OECD guidelines and include in vitro and in vivo models for sensitization, toxicity and safety.
Want to conduct the biological evaluation of your medical devices?
We have in vitro and in vivo capabilities, and expertise, including models for irritation, sensitization, toxicity and safety, that conform with ISO and OECD guidelines for medical device development.
IN VITRO |
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MTT colorimetric cell viability assay | L929 cells | TOX 18 |
Neutral Red colorimetric cell viability Assay | 3T3 cells | TOX 19 |
IN VITRO | ||
Micronucleus assay |
CHO-K1 Hamster cells |
In development |
Mouse Lymphoma assay |
L5178Y TK+/-- cells |
In development |
IN VIVO | ||
Mammalian erythrocyte micronucleus assay | Rat | TOX 17 |
IN VITRO | ||
Reconstituted human epidermis irritation assay | Episkin | TOX 21 |
IN OVO | ||
HET-CAM (Hen’s Egg Test Chorio Allantoic Membrane) |
Chicken egg | TOX 24 |
IN VIVO | ||
Skin irritation test | Rabbit | TOX 3 |
Acute dermal irritation (topical application) | Rabbit | TOX 22 |
Intradermal reactivity test (intracutaneous injection) | Rabbit | TOX 16 |
IN OVO | ||
Acute systemic toxicity (or repeated doses) alternative to embryotoxicity in mammals |
Chicken egg | TOX 23 |
IN VIVO | ||
Acute systemic toxicity | Mouse - Rat | TOX 11 |
Repeated doses systemic toxicity | Mouse - Rat | TOX 12 |
IN VIVO | ||
Local Lymph Nodes Assay (LLNA) |
Mouse | TOX 14 |
Guinea-Pig Maximization Test (GPMT) | Guinea-pig | In development |