Porsolt's experience in preclinical safety and efficacy has led to the development of models that focus on the liver and hepatic system. This is an important part of the development process to better understand the effects of compounds on the liver and hepatic system.

Carbon tetrachloride (CCl4) (acute model) Rat LI 1
Acetaminophen (acute model) Mouse LI 2
Concanavalin A (Con A) (acute model) Mouse LI 3
Bile Duct Ligation (BDL) (chronic model) Rat CV 2.7

Carbon tetrachloride (CCl4) acute model in rats

Carbon tetrachloride (CCl4) is an hepatic toxin widely used for experimental induction of liver injury and oxidative stress.

Additional in vitro capabilities

Starting with a core expertise in polarized primary cultures of rat hepatocytes, Fluofarma , our affiliate, set up a tool box to support to support drug discovery in hepatology.

From cell-based screening up to biomarker studies in liver tissues, we offer quantitative and automated approaches to characterize the effects of drug candidates on liver functions and explore their mechanism of action (MOA).