INFLAMMATION

INFLAMMATION

Inflammation is a complex mechanism gathering a number of cell response pathways to harmful stimuli, and can be either acute (initial response of the organism) or chronic (when the response is prolonged). Sustained inflammatory abnormalities are involved in a variety of disorders thereby making inflammatory pathways molecules attractive targets for drug discovery.

IN VITRO

• Immunology cell subsets immunophenotyping

• Immune cell response

• Cell physiology and metabolism

• Cell signaling

Multiple cellular models

IN VIVO
• Skin inflammation models Atopic and contact dermatitis  DER 2
• Psoriasis Imiquimod-induced model DER 1
• Lung inflammation Bleomycin-induced pulmonary fibrosis model RES 8
• Asthma Ovalbumin model RES 5

• Inflammatory pain

Multiple models

• Septic shock

LPS-induced model - Mouse PI29
LPS-induced neutrophilia - Ferret PI 33

• Air pouch

Carrageenan or LPS model - Mouse PI 24

•  Hyperthermia

Yeast-induced model - Mouse PI 11

• Carrageenan-induced edema evaluation

Reversal protocol - Rat PI 9
Preventive protocol - Mouse / Rat PI 17
• Carrageenan-induced abscess Rat PI 10

• TPA-induced ear edema

Mouse PI 18
BIOMARKER ANALYSIS & IMAGE ANALYSIS SOLUTIONS

• Immuno assays => ELISA, immunostaining, multiplexed immunophenotyping & biomarker detection

• High-throughput flow cytometry

• High-content histology

• Texture analysis for image quantification