Inflammation is a complex mechanism gathering a number of cell response pathways to harmful stimuli, and can be either acute (initial response of the organism) or chronic (when the response is prolonged). Sustained inflammatory abnormalities are involved in a variety of disorders thereby making inflammatory pathways molecules attractive targets for drug discovery.
in vitro models
• Immunology cell subsets | Immunophenotyping | Immune cell response
• Cell physiology and metabolism
• Cell signaling
in vivo models |
|
• Skin inflammation models | Psoriasis | Atopic and contact dermatitis |
Imiquimod-induced model | |
• Lung inflammation | Asthma | Bleomycin-induced pulmonary fibrosis model |
Ovalbumin model | |
• Septic shock |
LPS-induced model LPS-induced neutrophilia model |
• Air pouch | Carrageenan or LPS model |
• Hyperthermia |
Yeast-induced model |
• Inflammatory pain |
Carrageenan or CFA-induced paw edema MIA-induced chronic inflammatory pain (osteoarthritis model) |
Biomarker Analysis
• Immuno assays: ELISA | Immunostaining | Multiplexed immunophenotyping & biomarker detection
• High-throughput flow cytometry
• High-content histology
Image Analysis Solutions
• Texture analysis for image quantification
Based on the labeling of the different regions inside an image, it is possible to extract information that can describe the image content: Regions Of Interest (ROI) percentage, custom indices to help a pathologist in their diagnosis, tissue structures description, etc.