INFLAMMATION

INFLAMMATION

Inflammation is a complex mechanism gathering a number of cell response pathways to harmful stimuli, and can be either acute (initial response of the organism) or chronic (when the response is prolonged). Sustained inflammatory abnormalities are involved in a variety of disorders thereby making inflammatory pathways molecules attractive targets for drug discovery.

 

in vitro models

• Immunology cell subsets | Immunophenotyping | Immune cell response

• Cell physiology and metabolism

• Cell signaling

 in vivo models
• Skin inflammation models | Psoriasis Atopic and contact dermatitis
Imiquimod-induced model
• Lung inflammation | Asthma Bleomycin-induced pulmonary fibrosis model
Ovalbumin model
• Septic shock

LPS-induced model

LPS-induced neutrophilia model
• Air pouch Carrageenan or LPS model

•  Hyperthermia

 Yeast-induced model

• Inflammatory pain

Carrageenan or CFA-induced paw edema
TPA or Arachidonic acid-induced ear edema
Formalin/Capsaicin models
CFA-induced chronic inflammatory pain (monoarthritis model)

MIA-induced chronic inflammatory pain (osteoarthritis model)

Learn more on our inflammatory pain models

Biomarker Analysis

• Immuno assays: ELISA | Immunostaining | Multiplexed immunophenotyping & biomarker detection

• High-throughput flow cytometry

• High-content histology

Image Analysis Solutions

• Texture analysis for image quantification

Based on the labeling of the different regions inside an image, it is possible to extract information that can describe the image content: Regions Of Interest (ROI) percentage, custom indices to help a pathologist in their diagnosis, tissue structures description, etc.