Visceral smooth muscle

GASTROINTESTINAL SYSTEM

Porsolt has long-standing extensive expertise in gastrointestinal efficacy pharmacology and safety. We provide models that focus on different gastrointestinal indications and on different parts of the gastrointestinal system. Porsolt also continues to develop and validate new and relevant models.

Visceral smooth muscle

In vitro tissue pharmacology assays may serve to extend results obtained from radioligand binding assays. Tissues are isolated from smooth muscles of the gastrointestinal tract. Agonist or antagonist activities of the test substances are evaluated on quiescent or pre-contracted preparations.

Guinea-pig ileum: effects of SB 269970 on the relaxation induced by 5-carboxamidotryptamine on 1 µM histamine-precontracted strips