Ulcerogenic activity

GASTROINTESTINAL SYSTEM

Porsolt has long-standing extensive expertise in gastrointestinal efficacy pharmacology and safety. We provide models that focus on different gastrointestinal indications and on different parts of the gastrointestinal system. Porsolt also continues to develop and validate new and relevant models.

Ulcerogenic activity

Ulcerogenic/antiulcer activity in the rat: effects of indomethacin

 > Acute and sub-chronic effects

> Reference substance: Indomethacin (s.c., p.o.)

> Results:

     - Mean score (MS)
     - Percentage of stomach and duodenum showing ulcers (U%)
     - Ulcerogenic Index: UI = MS x U%

- = Not Significant, * = p < 0.05, ** = p < 0.01, *** = p < 0.001, n = 10 per group

- Single administration of indomethacin causes the occurrence of gastric ulcers, without significant ulcerogenic effect in the duodenum.

- Repeated administration of indomethacin causes the occurrence of gastric and duodenum ulcers.