Gastroparesis

GASTROINTESTINAL SYSTEM

Porsolt has long-standing extensive expertise in gastrointestinal efficacy pharmacology and safety. We provide models that focus on different gastrointestinal indications and on different parts of the gastrointestinal system. Porsolt also continues to develop and validate new and relevant models.

Gastroparesis

Gastroparesis is a chronic stomach disorder manifested by delayed emptying of solids and liquids without evidence of mechanical obstruction of the gastroduodenal junction.

Clonidine-induced gastroparesis in the rat

Effect of metoclopramide on clonidine-induced delayed gastric emptying

Gastric emptying in a rat model of Parkinson’s disease

Gastric emptying of a nutrient solid meal measured 16 weeks after bilateral 6-OHDA lesion into the striatum

Post-operative ileus in the mouse

Postoperative ileus (POI) is the transient impairment of gastrointestinal function developing as a consequence of abdominal surgery. POI is induced by gentle manipulation of the small intestine using a rolling motion with two cotton-tipped applicators. Intestinal transit is then measured about 24 hours after manipulation or sham procedure by evaluating the distribution along the gastrointestinal tract of phenol red content.

Effect of mosapride on post-operative ileus (Phenol red distribution)