Gastrointestinal transit

GASTROINTESTINAL SYSTEM

Porsolt has long-standing extensive expertise in gastrointestinal efficacy pharmacology and safety. We provide models that focus on different gastrointestinal indications and on different parts of the gastrointestinal system. Porsolt also continues to develop and validate new and relevant models.

Gastrointestinal transit

Gastrointestinal transit studies focus on the time of transit through the stomach, small intestine, caecum and colon. This is important for efficacy and safety evaluation of compounds on gastrointestinal motility.

Charcoal meal test

Gastrointestinal transit time in the small intestine, using the Charcoal Meal Test, focuses mainly on the measurement of small intestine transit time (the position of the charcoal front as a percentage of the total length of the small intestine) in rodents. A rough estimate of gastric emptying by measurement of the stomach contents can also be performed.

Distribution pattern of phenol red within the stomach, small bowel, caecum and colon

Gastric emptying and transit are measured by evaluation of the intestinal distribution of orally administered phenol red along the gastrointestinal tract.