Emesis-nausea

GASTROINTESTINAL SYSTEM

Porsolt has long-standing extensive expertise in gastrointestinal efficacy pharmacology and safety. We provide models that focus on different gastrointestinal indications and on different parts of the gastrointestinal system. Porsolt also continues to develop and validate new and relevant models.

Emesis-nausea

The assessment of emesis in ferrets is an established model that is used for the safety evaluation of compounds. It is also a valuable and commonly used model for evaluating efficacy against the emetic side effects of morphine-like treatments, cytotoxic agents or ionizing radiation.

Abdominal pressure recordings after cisplatin administration

The ferret is a useful and valid model for pharmacological research on acute and delayed emesis. Whereas early emesis can be easily quantified in animal models by visual observation, the evaluation of delayed emesis requires alternative methods.

We have recently described an automated method using telemetry together with specifically adapted software for identifying abdominal pressure changes related to retches or vomitting (Goineau et al., 2013).

Acute and/or delayed phase of emesis induced by cisplatin in the telemetered ferret

Synergistic effects of ondansetron and aprepitant on delayed phase of emesis

The automated method is reliable, valid and cost-effective for measuring emetic events over prolonged periods. This model creates new and important perspectives for the evaluation of combined therapies in cancer research and can facilitate the development of novel anti-emetic therapies (Goineau et al.,2014).