Colonic motility

GASTROINTESTINAL SYSTEM

Porsolt has long-standing extensive expertise in gastrointestinal efficacy pharmacology and safety. We provide models that focus on different gastrointestinal indications and on different parts of the gastrointestinal system. Porsolt also continues to develop and validate new and relevant models.

Colonic motility

Colonic motility is a critical process underlying the major functions of the large bowel, such as storage absorption, propulsion, and defecation. Disorders of colonic motility typically present with constipation or diarrhea.

Colonic Transit in the rat

Measurement of colon transit time is the primary tool in evaluating disorders of colonic motility. It is based on the expulsion time of a glass bead inserted into the distal colon.

Diarrheogenic/constipating activity in the rat

The measurement of fecal output (mouse or rat) is valuable in evaluating potential constipating or diarrheogenic activity of a test substance. The number of fecal pellets evacuated and their consistency (hard, soft or liquid feces) are evaluated.