GASTROINTESTINAL SYSTEM

GASTROINTESTINAL SYSTEM

Porsolt has long-standing extensive expertise in gastrointestinal efficacy pharmacology and safety. We provide models that focus on different gastrointestinal indications and on different parts of the gastrointestinal system. Porsolt also continues to develop and validate new and relevant models.

GASTROINTESTINAL TRANSIT

IN VIVO
Charcoal meal test Mouse - Rat GI 1
Distribution pattern of phenol red Mouse   GI 26
Gastrointestinal Transit - Learn More

COLONIC MOTILITY

IN VIVO
Colonic transit (bead model) Mouse - Rat GI 16
Fecal consistency Mouse - Rat GI 22
Anti-diarrhea (castor oil) Mouse - Rat GI 7
Colonic Motility - Learn More

EMESIS - NAUSEA

IN VIVO
Emesis induction Ferret GI 9
Early anti-emetic activity (morphine, cisplatin, emetine,…) Ferret GI 11
Early and delayed emesis (telemetry) Ferret GI 15
Pica behavior Rat GI 17
Emesis & Nausea - Learn More

GASTRIC EMPTYING

IN VIVO
Gastric emptying (phenol red test) Mouse - Rat GI 8
Gastric emptying (measurement of plasma acetaminophen levels) Rat GI 23
Gastric Emptying - Learn More

GASTROPARESIS

IN VIVO
Clonidine-induced delayed gastric emptying (liquid meal) Rat GI 20
Clonidine-induced delayed gastric emptying (solid meal) Rat GI 21
Post operative ileus Mouse GI 25
Gastroparesis - Learn More

ULCEROGENIC ACTIVITY

IN VITRO
Indomethacin-induced gastric mucosal cell damage Rat Gastric mucosal cells GI 29
IN VIVO
Ulcerogenic activity (acute and sub-chronic) Rat GI 2
Ulcerogenic activity prevention (induced by ethanol) Rat GI 19
Gastric acid secretion (Shay’s method) Mouse - Rat GI 3
Colorectal distension (CRD model) after acetic acid sensitization Rat GI 13
Colorectal distension (CRD model) after TNBS sensitization Rat GI 14
Ulcerogenic activity prevention (induced by indomethacin) Rat GI 27
Ulcerogenic Activity - Learn More

VISCERAL SMOOTH MUSCLE

EX VIVO
Isolated ileum Guinea-pig VSM 1
Isolated duodenum Rat VSM 2
Isolated colon Guinea-pig VSM 6
Visceral Smooth Muscle - Learn More

INTESTINAL MUCOSITIS

IN VIVO

NEW !

Chemotherapy-induced intestinal mucositis   Learn more

Mouse

GI 32

FOOD ALLERGY

IN VIVO
Peanut-induced allergy Mouse FA 1

NEW !

Beta-lactoglobulin-induced allergy

Mouse

FA 2

Food Allergy - Learn More

ADDITIONAL MODELS

IN VIVO
Conditioned taste aversion Rat GI 24
Salivation induction Mouse - Rat PNS 6
Pilocarpine salivation Mouse - Rat PNS 7