GASTROINTESTINAL SYSTEM
Porsolt has long-standing extensive expertise in gastrointestinal efficacy pharmacology and safety. We provide models that focus on different gastrointestinal indications and on different parts of the gastrointestinal system. Porsolt also continues to develop and validate new and relevant models.
GASTROINTESTINAL TRANSIT
| IN VIVO | ||
| Charcoal meal test | Mouse - Rat | GI 1 |
| Distribution pattern of phenol red | Mouse | GI 26 |
| Gastrointestinal Transit - Learn More | ||
COLONIC MOTILITY
| IN VIVO | ||
| Colonic transit (bead model) | Mouse - Rat | GI 16 |
| Fecal consistency | Mouse - Rat | GI 22 |
| Anti-diarrhea (castor oil) | Mouse - Rat | GI 7 |
| Colonic Motility - Learn More | ||
EMESIS - NAUSEA
| IN VIVO | ||
| Emesis induction | Ferret | GI 9 |
| Early anti-emetic activity (morphine, cisplatin, emetine,…) | Ferret | GI 11 |
| Early and delayed emesis (telemetry) | Ferret | GI 15 |
| Pica behavior | Rat | GI 17 |
| Emesis & Nausea - Learn More | ||
GASTRIC EMPTYING
| IN VIVO | ||
| Gastric emptying (phenol red test) | Mouse - Rat | GI 8 |
| Gastric emptying (measurement of plasma acetaminophen levels) | Rat | GI 23 |
| Gastric Emptying - Learn More | ||
GASTROPARESIS
| IN VIVO | ||
| Clonidine-induced delayed gastric emptying (liquid meal) | Rat | GI 20 |
| Clonidine-induced delayed gastric emptying (solid meal) | Rat | GI 21 |
| Post operative ileus | Mouse | GI 25 |
| Gastroparesis - Learn More | ||
ULCEROGENIC ACTIVITY
| IN VITRO | ||
| Indomethacin-induced gastric mucosal cell damage | Rat Gastric mucosal cells | GI 29 |
| IN VIVO | ||
| Ulcerogenic activity (acute and sub-chronic) | Rat | GI 2 |
| Ulcerogenic activity prevention (induced by ethanol) | Rat | GI 19 |
| Gastric acid secretion (Shay’s method) | Mouse - Rat | GI 3 |
| Colorectal distension (CRD model) after acetic acid sensitization | Rat | GI 13 |
| Colorectal distension (CRD model) after TNBS sensitization | Rat | GI 14 |
| Ulcerogenic activity prevention (induced by indomethacin) | Rat | GI 27 |
| Ulcerogenic Activity - Learn More | ||
VISCERAL SMOOTH MUSCLE
| EX VIVO | ||
| Isolated ileum | Guinea-pig | VSM 1 |
| Isolated duodenum | Rat | VSM 2 |
| Isolated colon | Guinea-pig | VSM 6 |
| Visceral Smooth Muscle - Learn More | ||
INTESTINAL MUCOSITIS
| IN VIVO | ||
|
NEW ! Chemotherapy-induced intestinal mucositis Learn more |
Mouse |
GI 32 |
FOOD ALLERGY
| IN VIVO | ||
| Peanut-induced allergy | Mouse | FA 1 |
|
NEW ! Beta-lactoglobulin-induced allergy |
Mouse |
FA 2 |
| Food Allergy - Learn More | ||
ADDITIONAL MODELS
| IN VIVO | ||
| Conditioned taste aversion | Rat | GI 24 |
| Salivation induction | Mouse - Rat | PNS 6 |
| Pilocarpine salivation | Mouse - Rat | PNS 7 |
Porsolt
Z.A. de Glatigné
53940 Le Genest-Saint-Isle, France
Telephone +33 2 43 69 36 07
Contact us
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