GASTROINTESTINAL SYSTEM

GASTROINTESTINAL SYSTEM

Porsolt has long-standing extensive expertise in gastrointestinal efficacy pharmacology and safety. We provide models that focus on different gastrointestinal indications and on different parts of the gastrointestinal system. Porsolt also continues to develop and validate new and relevant models.

GASTROINTESTINAL TRANSIT

Charcoal meal test Mouse - Rat GI 1
Distribution pattern of phenol red Mouse   GI 26
Gastrointestinal Transit - Learn More

COLONIC MOTILITY

Colonic transit (bead model) Mouse - Rat GI 16
Fecal consistency Mouse - Rat GI 22
Anti-diarrhea (castor oil) Mouse - Rat GI 7
Colonic Motility - Learn More

EMESIS - NAUSEA

Emesis induction Ferret GI 9
Early anti-emetic activity (morphine, cisplatin, emetine,…) Ferret GI 11
Early and delayed emesis (telemetry) Ferret GI 15
Pica behavior Rat GI 17
Emesis & Nausea - Learn More

GASTRIC EMPTYING

Gastric emptying (phenol red test) Mouse - Rat GI 8
Gastric emptying (measurement of plasma acetaminophen levels) Rat GI 23
Gastric Emptying - Learn More

GASTROPARESIS

Clonidine-induced delayed gastric emptying (liquid meal) Rat GI 20
Clonidine-induced delayed gastric emptying (solid meal) Rat GI 21
Post operative ileus Mouse GI 25
Gastroparesis - Learn More

ULCEROGENIC ACTIVITY

IN VITRO  Indomethacin-induced gastric mucosal cell damage Rat Gastric mucosal cells GI 29
Ulcerogenic activity (acute and sub-chronic) Rat GI 2
Ulcerogenic activity prevention (induced by ethanol) Rat GI 19
Gastric acid secretion (Shay’s method) Mouse - Rat GI 3
Colorectal distension (CRD model) after acetic acid sensitization Rat GI 13
Colorectal distension (CRD model) after TNBS sensitization Rat GI 14
Ulcerogenic activity prevention (induced by indomethacin) Rat GI 27
Ulcerogenic Activity - Learn More

VISCERAL SMOOTH MUSCLE

IN VITRO Isolated ileum Guinea-pig VSM 1
IN VITRO Isolated duodenum Rat VSM 2
IN VITRO Isolated colon Guinea-pig VSM 6 NEW!
Visceral Smooth Muscle - Learn More

ADDITIONAL MODELS

Conditioned taste aversion Rat GI 24
Salivation induction Mouse - Rat PNS 6
Pilocarpine salivation Mouse - Rat PNS 7
Peanut allergy model Mouse FA 1
Additional Models - Learn More