Dermatological diseases represent a major health problem due to the substantial patient population that is affected. Psoriasis, Allergic Contact Dermatitis (ACD) and Atopical Dermatitis (Allergic or Irritant Contact Dermatitis) are the major skin diseases of immunological origin.


Imiquimod-induced psoriasis inflammation-like model in mice

Psoriasis is characterized by cutaneous plaques with consistent scaling and erythema. Imiquimod-induced dermatitis in mice closely resembles human psoriasis. It is therefore a good model for the evaluation of new therapies for psoriasis.

With a preventive treatment, clobetasol and tacrolimus markedly reduce the PASI score, clobetasol being more potent. →

Clobetasol antagonizes the IMQ-induced thickening of the ear, while tacrolimus only has a slight effect.