DERMATOLOGY

DERMATOLOGY

Dermatological diseases represent a major health problem due to the substantial patient population that is affected. Psoriasis, Allergic Contact Dermatitis (ACD) and Atopical Dermatitis (Allergic or Irritant Contact Dermatitis) are the major skin diseases of immunological origin.

IN VITRO DERMATOLOGY    

in vitro cell migration

Multiple cellular models

in vitro angiogenesis

Multiple cellular models

Inflammation: released cytokines quantification

Multiple cellular models
Oxidative stress: mitochondrial toxicity & ROS production Multiple cellular models
Quantification of autophagy Cells & tissues
Antagonistic/agonistic properties on CGRP/RAMP receptors Multiple cellular models

Specialized adipocyte function & lipid metabolism

Adipocytes

Intracellular calcium mobilization

Multiple cellular models

Expression of biomarkers involved

Hair follicles

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IN VIVO MODELS
Imiquimod-induced psoriasis-like skin inflammation Mouse DER 1
Allergic Contact Dermatitis Pig  DER 2
Pruritogens-induced scratching behavior Mouse - Rat DER 3