DERMATOLOGY

DERMATOLOGY

Dermatological diseases represent a major health problem due to the substantial patient population that is affected. Psoriasis, Allergic Contact Dermatitis (ACD) and Atopical Dermatitis (Allergic or Irritant Contact Dermatitis) are the major skin diseases of immunological origin.

IN VITRO
Cytolysis Multiple cellular models PF 3.4
Cell cycle Multiple cellular models PF 3.8
Cell proliferation Multiple cellular models PF 3.9
Cell Migration wound healing Multiple cellular models PF 3.14
Autophagy (LC3B) HeLa cells PF 3.17
NF kB activation Multiple cellular models PF 3.23
cAMP quantification Multiple cellular models PF 3.34
Mitochondrial Membrane Potential Multiple cellular models PF 3.3
Glycerol release/lipolysis Adipocytes PF 7.1
Lipid, intracellular accumulation: neutral lipids Multiple cellular models PF 3.29
Lipid, intracellular accumulation: phospholipids Multiple cellular models PF 3.30
TNFalpha -induced cytotoxicity L929 cell line PF 4.1
H2O2-induced oxidative damage Keratinocytes PF 4.2

Total collagen formation

Normal human
dermal fibroblasts

PF 4.3

Angiogenesis

NHDF / HUVEC PF 4.4

Calcitonin gene-related peptide (CGRP) signaling pathway

HDMEC (Human Dermal Microvascular Endothelial Cells) PF 4.5

NEW!  Pollution – Reactive Oxygen Species

Keratinocytes PF 4.8

NEW!  Pollution – Lipid Peroxidation

Keratinocytes PF 4.9

NEW!  Pollution – Inflammatory cytokines release

Keratinocytes PF 4.10

Senescence induced-galactosidase

Multiple cellular models PF 4.11

Senescence wound healing

Keratinocytes PF 4.12

NEW!   Total collagen formation

Elderly human fibroblasts PF 4.13

Ocular irritation (HET-CAM)

Chicken eggs PF 4.14

Skin irritation 

Reconstituted Human Epidermis PF 4.15

Phagocytosis 

Primary Human Langerhans cells PF 4.16

Immuno-phenotyping

Skin Immune cells

PF 4.17

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IN VIVO
Imiquimod-induced psoriasis-like skin inflammation Mouse DER 1
Allergic Contact Dermatitis Pig  DER 2
Pruritogens-induced scratching behavior Mouse - Rat DER 3