CENTRAL NERVOUS SYSTEM
Porsolt offers models in all areas of psychopharmacology, epilepsy, sleep-wake, and neurodegenerative disorders. We are uniquely placed to offer a full range of CNS efficacy and safety pharmacology assessments, from basic models and regulatory tests, through the evaluation of abuse and dependence liability and proconvulsant risk using EEG.
• Transient MCAO (90 minutes) induced by a nylon thread
• Unilateral cortical and striatal lesion
• Sensori-motor deficits contralateral to the lesion
> Suggested approach
- Neuroprotection: treatments administered on the day of surgery and/or during a few days after surgery.
- Neuroregeneration: treatments administered chronically during several weeks after surgery.
> Experimental procedures
- Neurological score
- Removal of adhesive
- Foot fault
> Other avalaible tests:
- Evaluation of motor coordination: accelerating rotarod test / beam walking test
- Lesion size induced by transient MCAo: thionin staining