CENTRAL NERVOUS SYSTEM
Porsolt offers models in all areas of psychopharmacology, epilepsy, sleep-wake, and neurodegenerative disorders. We are uniquely placed to offer a full range of CNS efficacy and safety pharmacology assessments, from basic models and regulatory tests, through the evaluation of abuse and dependence liability and proconvulsant risk using EEG.
ASSAYS PREDICTIVE OF ANXIOLYTIC EFFICACY |
EFFECTS |
TESTS
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Vogel conflict / 4 Plates test
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Stress-induced hyperthermia /Fear Potentiated Startle (FPS)
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Elevated plus maze /Light-dark box /Marble burying /Emotional hypophagia /Fear Potentiated Startle (FPS)
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SCREENING |
EFFECTS
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TESTS |
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Mouse Marble Burying |
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Reduction of “behavioral despair“ / Forced swim (Porsolt) test |
ADVANCED/ EFFICACY |
EFFECTS | TESTS |
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Open Space Swim Test (OSST) |
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Chronic corticosterone model in collaboration with preferred partner Chronic Mild Stress (CMS) |
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Differential Reinforcement of Low rate (DRL30) |
POSITIVE SYMPTOMS | > Hyperactivity induced by Amphetamine, Apomorphine, MK-801, PCP > Amphetamine-induced stereotypies > Apomorphine-induced climbing |
SENSORY FILTERING PRE-ATTENTIONAL PROCESSES |
> Disruption of pre-pulse inhibition (PPI) by apomorphine, MK-801 or PCP (in development) |
COGNITIVE DEFICITS |
> Deficits induced by MK-801 or PCP: Morris water mazeSocial recognition Passive avoidance Delayed alternation Operant reversal |
NEGATIVE SYMPTOMS |
> Social interaction deficits - acute MK-801, in development |
SIDE EFFECT LIABILITY |
> Induction of catalepsy > Effects on glucose metabolism OGTTIVGTT Weight gain |