General screening

CENTRAL NERVOUS SYSTEM

Porsolt offers models in all areas of psychopharmacology, epilepsy, sleep-wake, and neurodegenerative disorders. We are uniquely placed to offer a full range of CNS efficacy and safety pharmacology assessments, from basic models and regulatory tests, through the evaluation of abuse and dependence liability and proconvulsant risk using EEG.

General screening

GENERAL EFFECTS TEST
General effects on behavior Irwin Test
Locomotor activity Activity meter test
Motor skills Foot-fault and removal of adhesive tests
Motor coordination Rotarod and beam walking tests
Hypnotic interaction Barbital or ethanol interaction tests

ACTIVITY METER TEST

The method detects stimulant or sedative activity.

The activity meter consists of cages contained within a darkened cabinet.

Each cage is equipped with photocell assemblies in order to measure the number of horizontal and vertical movements of each animal.

ROTAROD TEST (FIXED SPEED)

The method detects neurological deficits, in particular motor coordination

- Rodents are placed on a rod rotating at a fixed speed

- The number of animals which drop off the rod within 3 minutes is counted and the drop-off times recorded (maximum: 3 minutes)