Cognition & dementia

CENTRAL NERVOUS SYSTEM

Porsolt offers models in all areas of psychopharmacology, epilepsy, sleep-wake, and neurodegenerative disorders. We are uniquely placed to offer a full range of CNS efficacy and safety pharmacology assessments, from basic models and regulatory tests, through the evaluation of abuse and dependence liability and proconvulsant risk using EEG.

Cognition & dementia

POTENTIAL PRECLINICAL CHARACTERISATION & DIFFERENTIATION OF NOVEL COGNITIVE ENHANCING AGENTS

DISEASE-RELEVANT MODELS FOR COGNITION

> Scopolamine and aged rats
MWM, DA/DNMTS, OR, SR, PA

> PCP
DA/DNMTS, OR

> MK-801
MWM, DA/DNMTS, OR, SR, PA, SI

> Normal rats
DA/DNMTS, OR
AD/MCI Schizophrenia ADHD

PRECLINICAL COGNITIVE TESTS

Working Memory

Operant Delayed Alternation (DA)/DNMTS

Passive Avoidance (PA)

Episodic Memory/ Long-Term Memory

Morris Water-Maze (MWM)

 (Acquisition and Retention)

Executive Control/Function

Operant Reversal Learning (OR)

(Operant Set-Shifting under validation)

Recognition Memory

Social Recognition (SR)

Attention/Vigilance

Operant Delayed Alternation / DNMTS

(reaction times and response failures)

Perception

PPI startle

Social/Emotive Processing

Social Recognition (SR)

Scopolamine-induced impairment in delayed alternation / DNMTS: acquisition

*= p < 0.05, ** = p < 0.01 and *** = p < 0.001 when comparing vehicle (saline) with scopolamine (0.25 and 0.5 mg/kg s.c.), n = 11-12 per group

Scopolamine robustly impairs the acquisition of the rule

Donepezil improves memory in the social recognition test with normal forgetting

Compared with first contact: * = p < 0.05, ** = p < 0.01, *** = p < 0.001 (investigation duration), n = 12 per group

Donepezil reliably improves social memory after a 120 min temporal delay