CENTRAL NERVOUS SYSTEM

CENTRAL NERVOUS SYSTEM

Porsolt offers models in all areas of psychopharmacology, epilepsy, sleep-wake, and neurodegenerative disorders. We are uniquely placed to offer a full range of CNS efficacy and safety pharmacology assessments, from basic models and regulatory tests, through the evaluation of abuse and dependence liability and proconvulsant risk using EEG.

CNS GENERAL SCREENING

Primary observation (Irwin) Mouse - Rat CNS 1.1
Activity meter Mouse - Rat CNS 1.2
Rotarod Mouse - Rat CNS 1.5
Accelerating rotarod Mouse - Rat CNS 1.17
Beam walking Mouse - Rat CNS 1.12
Foot-fault Rat CNS 1.16
Removal of adhesive Rat CNS 1.14
Neurological score Rat CNS 1.15
Barbiturate interaction (sleep induction) Mouse - Rat CNS 1.8
Ethanol interaction (sleep induction) Mouse - Rat CNS 1.9
Tetrad test Mouse  CNS 1.13
Rectal temperature (option: implants) Mouse - Rat CNS 1.11
Odor discrimination Rat CNS 1.18
Grip strength Mouse - Rat CNS 1.19
CNS General screening - Learn More

PSYCHIATRIC DISEASES

DEPRESSION

Reserpine Mouse - Rat CNS 2.1
Behavioral despair Mouse - Rat CNS 2.5
Open space swimming Mouse CNS 2.8
Differential reinforcement of low rate (DRL 30) Rat CNS 2.6
Chronic Mild Stress Mouse CNS 2.10

ANXIETY

Four plates Mouse CNS 3.1
Staircase Mouse CNS 3.2
Elevated plus-maze Mouse - Rat - Gerbil CNS 3.3
Light-dark box Mouse CNS 3.4
Novelty-induced hypophagia Mouse - Rat CNS 3.5
Stress-induced hyperthermia (group-housed animals) Mouse CNS 3.6
Stress-induced hyperthermia (singly-housed animals) Option: implants Mouse CNS 3.17
Chronic corticosterone model Mouse Partnership
Marble burying Mouse CNS 3.7
Vogel conflict Rat CNS 3.8
Fear potentiated startle reflex Rat CNS 3.13

PSYCHOSIS

Amphetamine hyperactivity Mouse - Rat CNS 4.1
Amphetamine stereotypy Mouse - Rat CNS 4.2
Apomorphine climbing Mouse CNS 4.12
Low dose apomorphine Mouse CNS 4.5
Mescaline scratching Mouse CNS 4.6
MK-801 hyperactivity Mouse - Rat CNS 4.13
PCP hyperactivity Mouse - Rat CNS 4.8
Catalepsy Mouse - Rat CNS 4.9
Prepulse inhibition (deficit induced by apomorphine) Rat CNS 4.11
Prepulse inhibition (deficit induced by MK-801) Rat CNS 4.14
Prepulse inhibition (deficit induced by PCP) Rat CNS 4.15
Social investigation (deficit induced by MK-801) Rat CNS 4.16
Psychiatric diseases - Learn More

EPILEPSY

Maximal electroshock Mouse - Rat CNS 5.1
Electroconvulsive threshold Mouse - Rat - Gerbil CNS 5.2
Pentylenetetrazole seizures Mouse - Rat CNS 5.3
Intravenous PTZ seizure threshold Rat CNS 5.11
Strychnine convulsions Mouse - Rat CNS 5.4
Picrotoxin convulsions Mouse - Rat CNS 5.5
Bicuculline convulsions Mouse - Rat CNS 5.6
Kainic acid convulsions Rat CNS 5.10
Audiogenic seizures Mouse CNS 5.7
6 Hz psychomotor Mouse - Rat - Gerbil CNS 5.9
GBL-induced absence epilepsy (EEG telemetry) Mouse CNS 5.12
Genetic absence epilepsy GAERS Rat Contact us
Mesial temporal lobe epilepsy MTLE Mouse Contact us
Electrical amygdala kindling (Electrophysiology) Rat CNS 9.3
Epilepsy - Learn More

COGNITION & DEMENTIA

EXPERIMENTAL PROCEDURES

Passive avoidance Mouse - Rat CNS 6.19
Morris water maze (single session) Rat CNS 6.16
Morris water maze (4 sessions + probe) Mouse - Rat CNS 6.17
Social recognition (30 minute retention) Rat CNS 6.20
Social recognition (120 minute retention) (delay-induced forgetting) Rat CNS 6.21
Delayed alternation (acquisition) Rat CNS 6.13
Delayed alternation (stabilized performance) Rat CNS 6.15
Operant reversal Rat CNS 6.24

MODELS OF PHARMACOLOGICALLY- INDUCED AMNESIA

  • Scopolamine - induced amnesia
Passive avoidance Mouse - Rat CNS 6.1
Morris water maze (single session) Rat CNS 6.3
Morris water maze (4 sessions + probe) Rat CNS 6.18
Social recognition (30 minute retention) Rat CNS 6.5
Delayed alternation (stabilized performance) Rat CNS 6.28
Operant reversal Rat CNS 6.32
  • Diazepam - induced amnesia
Passive avoidance Mouse - Rat CNS 6.27
  • MK 801 - induced amnesia
Passive avoidance Rat CNS 6.26
Morris water maze (4 sessions + probe) Rat CNS 6.23
Social recognition (30 minute retention) Rat CNS 6.33
Delayed alternation (stabilized performance) Rat CNS 6.29
Operant reversal Rat CNS 6.31
  • PCP - induced amnesia
Delayed alternation (stabilized performance) Rat CNS 6.30
Operant reversal Rat CNS 6.37

AGED-RELATED DEFICIT

Social recognition Aged Rat CNS 6.9
Morris water maze (4 sessions + probe) Aged Rat CNS 6.7
Delayed alternation (acquisition) Aged Rat CNS 6.10
Delayed alternation (stabilized performance) Aged Rat CNS 6.11
Operant reversal Aged Rat CNS 6.34
Cognition & Dementia - Learn More

DRUG ABUSE & DEPENDENCE

Naloxone-precipitated withdrawal (Saelens) Mouse CNS 7.1
Flumazenil-precipitated withdrawal (ECS threshold) Mouse CNS 7.2
Non-precipitated withdrawal (option: telemetry) Rat CNS 7.3
Opiate tolerance (hot plate) Mouse - Rat CNS 7.4
Place preference Rat CNS 7.5
Self-administration (initiation) Rat CNS 7.6
Self-administration (substitution) Rat CNS 7.7
Self-administration (reinstatment) Rat CNS 7.9
Self-administration (progressive ratio) Rat CNS 7.10
Drug discrimination Rat CNS 7.8
Drug abuse & Dependence - Learn More

ELECTROPHYSIOLOGY

CONCIOUS ANIMALS (TELEMETRY)

Quantified EEG Mouse - Rat CNS 9.7
Sleep/wakefulness cycle Rat CNS 9.2
Electrical amygdala kindling Rat CNS 9.3
EEG trace monitoring Mouse - Rat - Dog CNS 9.5
Electrophysiology - Learn More

NEURODEGENERATION & STROKE

IN VITRO Glutamate-induced exitotoxicity Rat cortical or hippocampal neurons CNS 10.13

HUNTINGTON DISEASE

Motor function and neuroscore - Subchronic 3-NPA Rat CNS 10.8

  ↓ EXPERIMENTAL PROCEDURES

     Activity meter

     Rotarod
     Lesion volume

PARKINSON DISEASE

IN VITRO 6-OHDA-induced toxicity SH-SY5Y cells CNS 10.15

IN VITRO 6-OHDA-induced toxicity
(Neurite outgrowth of dopamine neurons)

ICell® DopaNeurons CNS 10.16
IN VITRO Rotenone-induced toxicity
(Neurite outgrowth of dopamine neurons)
Rat mesencephalic cultures CNS 10.17
Tremor
Tacrine-induced tremulous jaw-movements (TJM)
Rat CNS 10.1
Turning behavior
Unilateral medial forebrain bundle (MFB) 6-OHDA lesion
Rat CNS 10.7
Stepping behavior
Unilateral medial forebrain bundle (MFB) 6-OHDA lesion
Rat CNS 10.2
L-DOPA dyskinesia
Unilateral medial forebrain bundle (MFB) 6-OHDA lesion
Rat CNS 10.5
Cognitive deficit
Bilateral striatal 6-OHDA lesion
Rat CNS 10.9
Psychosis-like-behaviour
Bilateral striatal 6-OHDA lesion
Rat CNS 10.12
Parkinson's Disease - Learn More

ALZHEIMER DISEASE

IN VITRO Tau hyperphosphorylation Rat cortical culture PF 9.3
IN VITRO Amyloid Beta1-42 induced neurotoxicity Rat cortical culture PF 9.10
Streptozotocin (STZ) - induced cognitive deficit Rat CNS 10.11

     ↓ EXPERIMENTAL PROCEDURES

        Morris water maze

        Delayed alternation
   Alzheimer's Disease - Learn More

STROKE

IN VITRO NMDA-induced excitotoxicity  Rat cortical neurons CNS 10.21
Intrastriatal NMDA administration   Mouse CNS 10.14

      ↓ EXPERIMENTAL PROCEDURES:

        Lesion volume

Transient focal cerebral ischemia
Middle Cerebral Artery Occlusion
Rat CNS 10.3

      ↓ EXPERIMENTAL PROCEDURES:

        Beam walking

        Foot-fault
        Removal of adhesive
        Neurological score
        Lesion volume
Stroke - Learn More