Hypertension

CARDIOVASCULAR SYSTEM

Porsolt has an extensive portfolio of cardiovascular procedures, ranging from standard cardiovascular telemetry studies for safety evaluation, to pathophysiological models for specific therapeutic areas. Porsolt also possesses considerable expertise with in vitro models, providing clients with a comprehensive assessment of all aspects of cardiovascular function.

Hypertension

Monocrotaline-induced pulmonary arterial hypertension in the rat

MCT induced significant right ventricular hypertension, systemic hypertension, right ventricular hypertrophy (Day 21 or Day 28) and death (from Day 26).

Mean s.e.m. (hemodynamics: n = 7-8 at D0 and D21, n = 3 at D28 ; survival: n=10) Inter-group comparisons (D21/D28 versus D0) : no indication = not significant; * = p < 0.05; ** = p < 0.01; *** = p < 0.001