Hemodynamics

CARDIOVASCULAR SYSTEM

Porsolt has an extensive portfolio of cardiovascular procedures, ranging from standard cardiovascular telemetry studies for safety evaluation, to pathophysiological models for specific therapeutic areas. Porsolt also possesses considerable expertise with in vitro models, providing clients with a comprehensive assessment of all aspects of cardiovascular function.

Hemodynamics

Hemodynamic evaluation in the anesthetized dog

PARAMETERS

     - Mean, systolic and diastolic aortic blood pressure
     - Left ventricular pressure
     -
Left ventricular end diastolic blood pressure
     -
Cardiac output
     -
Renal blood flow (option: Left circumflex coronary artery blood flow and resistance)
     - Heart rate
     -
Pulmonary artery blood pressure
     -
Pulmonary capillary wedge pressure
     - dP/dt max, min
     -
Total peripheral resistance
     -
Index of arteriolar renal resistance
     -
Stroke volume
     -
Systolic ejection time
     - Tension time index
     -
Left cardiac work
     - PR interval
     - QT interval
     - Corrected QT interval

Parameters highlighted can also be evaluated by telemetry in the conscious dog.

 

Effects of diltiazem 1 mg/kg i.v. bolus (open chest)