CARDIOVASCULAR SYSTEM

CARDIOVASCULAR SYSTEM

Porsolt has an extensive portfolio of cardiovascular procedures, ranging from standard cardiovascular telemetry studies for safety evaluation, to pathophysiological models for specific therapeutic areas. Porsolt also possesses considerable expertise with in vitro models, providing clients with a comprehensive assessment of all aspects of cardiovascular function.

HEMODYNAMICS

CONCIOUS ANIMALS (TELEMETRY)
Arterial blood pressure, heart rate ± ECG Mouse - Rat - Dog - Guinea-pig - Mini-pig CV 1.4
Pulmonary arterial blood pressure, heart rate and ECG Dog CV 1.14
Left ventricular pressure, heart rate ± ECG Rat - Dog CV 1.16
Right ventricular pressure and heart rate Rat CV 1.15
ANESTHETIZED ANIMALS
Arterial blood pressure, heart rate and ECG Rat - Guinea-pig - Rabbit CV 1.1
Regional blood flow Rat CV 1.5
Systemic, cardiac, renal and pulmonary hemodynamics Dog CV 1.7
Systemic and cardiac hemodynamics (cardiac denervated animal) Dog CV 1.11
Bezold-Jarish reflex (capsaicin or 5-HT) Rat CV 1.12
Hemodynamics - Learn More

HYPERTENSION

IN VITRO

NEW!

Endothelial cell activation

HUVECs

PF 1.6

IN VIVO
Arterial blood pressure and heart rate (telemetry) SH Rat CV 2.4
Bile duct ligation-induced portal vein hypertension (telemetry) Rat CV 2.7
Chronic DOCA - salt hypertension (low renin model) Rat CV 2.3
Chronic (2K1C) Goldblatt hypertension (high renin model) Rat CV 2.5
5/6 nephrectomy Rat REN 3
Arterial blood pressure and heart rate (anesthetized animals) SH Rat CV 2.1
Monocrotaline-induced pulmonary hypertension (anesthetized animals) Rat CV 2.6
Monocrotaline-induced pulmonary hypertension (telemetry) Rat CV 2.8
Hypertension - Learn More

ARRHYTHMIAS & CARDIAC TOXICITY

IN VIVO
Aconitine induced arrhythmias (anesthetized animals) Rat - Dog CV 3.3
Digoxin ventricular arrhythmias (anesthetized animals) Guinea-pig CV 3.5
Torsades de Pointes arrhythmias (modified Carlsson model) Rabbit CV 3.9
Arrhytmias & Cardiac Toxicity - Learn More

CARDIAC ACTIVITY RECORDING

IN VITRO

NEW !

Calcium assay

iPSC-derived cardiomyocytes:
iCell2®

PF 1.7

NEW !

MEA assay

iPSC-derived cardiomyocytes:
MEA assay Cor 4U® – iCell2®

CV 5.14

Cardiac risk assessment  - Learn more

hERG channel HEK 293 CV 5.6
hERG trafficking HEK 293 CV 5.10
hNav1.5 channel HEK 293 CV 5.7
hKir2.1 channel HEK 293 CV 5.8
hKir2.1 trafficking HEK 293 CV 5.13
hCav1.2 channel HEK 293 CV 5.9
EX VIVO
Spontaneously beating right atrium Guinea-pig – Rabbit CV 5.1
Stimulated left atrium Guinea-pig – Rabbit CV 5.11
Purkinje fiber Rabbit – Dog CV 5.5
Papillary muscle Guinea-pig CV 5.12
Cardiac Electrophysiology - Learn More

AUTONOMIC NERVOUS SYSTEM

IN VIVO
Pithed rat (anesthetized animals) Rat CV 6.1
Postural hypotension (anesthetized animals) Rat CV 6.3
Postural hypotension (telemetry) Rat CV 6.4
Autonomic Nervous System - Learn More

ISOLATED VASCULAR BEDS

EX VIVO
Isolated thoracic aorta Rat - Rabbit CV 8.1
Isolated saphenous vein Rabbit - Dog CV 8.2
Isolated mesenteric artery Dog CV 8.4
Isolated Vascular Beds - Learn More