CARDIOVASCULAR SYSTEM

CARDIOVASCULAR SYSTEM

Porsolt has an extensive portfolio of cardiovascular procedures, ranging from standard cardiovascular telemetry studies for safety evaluation, to pathophysiological models for specific therapeutic areas. Porsolt also possesses considerable expertise with in vitro models, providing clients with a comprehensive assessment of all aspects of cardiovascular function.

HEMODYNAMICS

CONCIOUS ANIMALS (TELEMETRY)

Arterial blood pressure, heart rate ± ECG Mouse - Rat - Dog - Guinea-pig - Mini-pig CV 1.4
Pulmonary arterial blood pressure, heart rate and ECG Dog CV 1.14
Left ventricular pressure, heart rate ± ECG Rat - Dog CV 1.16
Right ventricular pressure and heart rate Rat CV 1.15

ANESTHETIZED ANIMALS

Arterial blood pressure, heart rate and ECG Rat - Guinea-pig - Rabbit CV 1.1
Regional blood flow Rat CV 1.5
Systemic, cardiac, renal and pulmonary hemodynamics Dog CV 1.7
Systemic and cardiac hemodynamics (cardiac denervated animal) Dog CV 1.11
Bezold-Jarish reflex (capsaicin or 5-HT) Rat CV 1.12
Hemodynamics - Learn More

HYPERTENSION

Arterial blood pressure and heart rate (telemetry) SH Rat CV 2.4
Bile duct ligation-induced portal vein hypertension (telemetry) Rat CV 2.7
Chronic DOCA - salt hypertension (low renin model) Rat CV 2.3
Chronic (2K1C) Goldblatt hypertension (high renin model) Rat CV 2.5
5/6 nephrectomy Rat REN 3
Arterial blood pressure and heart rate (anesthetized animals) SH Rat CV 2.1
Monocrotaline-induced pulmonary hypertension (anesthetized animals) Rat CV 2.6
Monocrotaline-induced pulmonary hypertension (telemetry) Rat CV 2.8
Hypertension - Learn More

ARRHYTHMIAS & CARDIAC TOXICITY

Aconitine induced arrhythmias (anesthetized animals) Rat - Dog CV 3.3
Digoxin ventricular arrhythmias (anesthetized animals) Guinea-pig CV 3.5
Torsades de Pointes arrhythmias (modified Carlsson model) Rabbit CV 3.9
Arrhytmias & Cardiac Toxicity - Learn More

CARDIAC ELECTROPHYSIOLOGY

IN VITRO Spontaneously beating right atrium Guinea-pig - Rabbit CV 5.1
IN VITRO Stimulated left atrium Guinea-pig - Rabbit CV 5.11
IN VITRO Purkinje fiber Rabbit - Dog CV 5.5
IN VITRO Papillary muscle Guinea-pig CV 5.12
IN VITRO hERG channel HEK 293 CV 5.6
IN VITRO hERG trafficking HEK 293 CV 5.10
IN VITRO hNav1.5 channel HEK 293 CV 5.7
IN VITRO hKir2.1 channel HEK 293 CV 5.8
IN VITRO hKir2.1 trafficking HEK 293 CV 5.13
IN VITRO hCav1.2 channel HEK 293 CV 5.9
Cardiac Electrophysiology - Learn More

IN VITRO Human cardiomyocytes

Cor 4U® - iCell®

CV5.14

Cardiac risk assessment  - Learn more

AUTONOMIC NERVOUS SYSTEM

Pithed rat (anesthetized animals) Rat CV 6.1
Postural hypotension (anesthetized animals) Rat CV 6.3
Postural hypotension (telemetry) Rat CV 6.4
Autonomic Nervous System - Learn More

ISOLATED VASCULAR BEDS

IN VITRO Isolated thoracic aorta Rat - Rabbit CV 8.1
IN VITRO Isolated saphenous vein Rabbit - Dog CV 8.2
IN VITRO Isolated mesenteric artery Dog CV 8.4
Isolated Vascular Beds - Learn More