Biomarkers enable to evaluate and characterize a physiopathological context, and to predict drug response, safety and efficiency at preclinical and clinical stages.
Using automated and multiplex high-content analysis technologies, we offer to quantify biomarkers at single-cell resolution in blood and tissue samples.
In the context of preclinical studies and clinical trials, we quantify biomarkers in blood or tissue samples to:
> Assess in vivo drug efficacy and safety
> Prove in vivo drug mechanism of action
> Perform pharmacokinetic and bioequivalence studies
> Stratify patients in trials
Our biomarker analysis services can be performed a wide range of tissue samples in different formats:
Tissue samples | Tissue sources | Tissue origin |
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Large experimental series are processed and analyzed by automated high-content histology:
> High-throughput image acquisition of IF/IHC-stained tissue sections or tissue microarrays
> Multiplexed biomarker quantification through cytometric image-based analysis
> Automated biomarkers analysis and quantification at the single-cell level (biomarker expression levels and biomarker subcellular distribution) using proprietary Cytosurfer® software
> High-throughput: blood samples are processed in 96-/384-well plates
> Multiplexed immunophenotyping & biomarker detection by automated 3-laser flow cytometry
In vitro (culture supernatant) and ex vivo (serum, plasma) samples are processed and analyzed by automated high-throughput cytometry:
> Up to 6 cytokines analyzed in multiplex
> Pre-defined set of an immune response pathway (kit) or customized set of cytokines (flex set)
> High-throughput sample acquisition of samples stained in multiplex
> Multiplexed quantification of cytokines expression through cytometry based analysis